Document Detail

Giant T waves simulating apical hypertrophic myocardiopathy that disappear with sodium nitroprusside administration. Case report of pheochromocytoma.
MedLine Citation:
PMID:  1919387     Owner:  NLM     Status:  MEDLINE    
Giant inverted T waves (amplitude greater than 1 mV) in precordial leads have been described in various disease processes. However, the pathophysiology of these anomalies has not been studied in depth. This paper analyzes repolarization abnormalities occurring in a case of pheochromocytoma in which giant T waves were unaffected by alpha-adrenergic blockade but were affected by administration of sodium nitroprusside. It is postulated that the probable cause of this aberration is myocardial ischemia of noncoronary origin resulting from an imbalance of supply and demand of oxygen that is relieved by the hemodynamic action of nitroprusside when left ventricular wall stress is reduced.
S Trevethan; R Castilla; G Medrano; A de Michelli
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  24     ISSN:  0022-0736     ISO Abbreviation:  J Electrocardiol     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-11-14     Completed Date:  1991-11-14     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  267-75     Citation Subset:  IM    
Department of Medicine (Cardiology) National Institute of Cardiology Ignacio Chávez, México, D.F.
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MeSH Terms
Adrenal Gland Neoplasms / physiopathology*
Blood Pressure
Cardiomyopathy, Hypertrophic / pathology,  physiopathology*
Electrocardiography* / drug effects
Heart Rate
Nitroprusside / administration & dosage*
Phenoxybenzamine / administration & dosage
Pheochromocytoma / physiopathology*
Reg. No./Substance:
15078-28-1/Nitroprusside; 59-96-1/Phenoxybenzamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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