| Giant cell arteritis: epidemiology, diagnosis, and management. | |
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MedLine Citation:
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PMID: 20857242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Giant cell arteritis (GCA), also called temporal arteritis, is a vasculitis that affects large and middle-sized blood vessels--with predisposition to the involvement of cranial arteries derived from the carotid artery--in individuals older than 50 years of age. Familial aggregation of GCA has been observed. Incidence of GCA is higher in white individuals than those of other ethnicities, particularly those of Scandinavian background. A temporal artery biopsy is the gold standard test for the diagnosis of GCA. Several imaging modalities, in particular ultrasonography, are useful in the diagnosis of GCA. Corticosteroids are the cornerstone of treatment in GCA. Alternative, steroid-sparing drugs, particularly methotrexate, should be considered in GCA patients with severe corticosteroid-related side effects and/or in those who require prolonged corticosteroid therapy due to relapses of the disease. |
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Authors:
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Miguel A Gonzalez-Gay; Cristina Martinez-Dubois; Mario Agudo; Orlando Pompei; Ricardo Blanco; Javier Llorca |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current rheumatology reports Volume: 12 ISSN: 1534-6307 ISO Abbreviation: Curr Rheumatol Rep Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888970 Medline TA: Curr Rheumatol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 436-42 Citation Subset: IM |
Affiliation:
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Rheumatology Division, Hospital Universitario Marques de Valdecilla, Avenida de Valdecilla s/n, 39008, IFIMAV, Santander, Cantabria, Spain. miguelaggay@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Giant Cell Arteritis* / diagnosis, drug therapy, epidemiology Glucocorticoids / therapeutic use Humans Immunosuppressive Agents / therapeutic use Methotrexate / therapeutic use Middle Aged Temporal Arteries / pathology*, ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunosuppressive Agents; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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