Document Detail


Giant cell arteritis: epidemiology, diagnosis, and management.
MedLine Citation:
PMID:  20857242     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Giant cell arteritis (GCA), also called temporal arteritis, is a vasculitis that affects large and middle-sized blood vessels--with predisposition to the involvement of cranial arteries derived from the carotid artery--in individuals older than 50 years of age. Familial aggregation of GCA has been observed. Incidence of GCA is higher in white individuals than those of other ethnicities, particularly those of Scandinavian background. A temporal artery biopsy is the gold standard test for the diagnosis of GCA. Several imaging modalities, in particular ultrasonography, are useful in the diagnosis of GCA. Corticosteroids are the cornerstone of treatment in GCA. Alternative, steroid-sparing drugs, particularly methotrexate, should be considered in GCA patients with severe corticosteroid-related side effects and/or in those who require prolonged corticosteroid therapy due to relapses of the disease.
Authors:
Miguel A Gonzalez-Gay; Cristina Martinez-Dubois; Mario Agudo; Orlando Pompei; Ricardo Blanco; Javier Llorca
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  12     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2011-01-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  436-42     Citation Subset:  IM    
Affiliation:
Rheumatology Division, Hospital Universitario Marques de Valdecilla, Avenida de Valdecilla s/n, 39008, IFIMAV, Santander, Cantabria, Spain. miguelaggay@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Giant Cell Arteritis* / diagnosis,  drug therapy,  epidemiology
Glucocorticoids / therapeutic use
Humans
Immunosuppressive Agents / therapeutic use
Methotrexate / therapeutic use
Middle Aged
Temporal Arteries / pathology*,  ultrasonography
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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