| Gianotti-Crosti syndrome presenting as lichenoid dermatitis. | |
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MedLine Citation:
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PMID: 10770438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Papular acrodermatitis of childhood (Gianotti-Crosti syndrome) is an uncommon, self-limited disease characterized by an erythematous papular eruption symmetrically distributed on the face and limbs and mild lymphadenopathy, thought to be of viral origin. The histopathologic findings are nonspecific and include focal parakeratosis, mild spongiosis, superficial perivascular infiltrate, papillary dermal edema, and extravasated red blood cells. Interface changes with some basal vacuolization may be present, but are not a conspicuous feature. We present a 2 1/2-year-old boy with multiple papules and plaques on the face and extremities and cervical lymphadenopathy. Histopathologic analysis showed compact orthokeratosis, focal parakeratosis, hypergranulosis, psoriasiform epidermal hyperplasia, and a dense lichenoid lymphohistiocytic infiltrate with extensive exocytosis of mononuclear cells. Immunoperoxidase staining with CD 1 a revealed clusters of Langerhans cells in the epidermis and in the papillary dermis. In view of the clinical findings, a diagnosis of Gianotti-Crosti syndrome was made. Although there are a few reports describing a lichenoid pattern of infiltration in Gianotti-Crosti syndrome, this histologic pattern is not widely known. This case is presented to illustrate the fact that Gianotti-Crosti syndrome can present as lichenoid dermatitis, and, especially in children, should be added to the differential diagnoses of lichenoid infiltrates. |
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Authors:
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C M Stefanato; L J Goldberg; W K Andersen; J Bhawan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American Journal of dermatopathology Volume: 22 ISSN: 0193-1091 ISO Abbreviation: Am J Dermatopathol Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-05-31 Completed Date: 2000-05-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7911005 Medline TA: Am J Dermatopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 162-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Boston University School of Medicine, Massachusetts 02118, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrodermatitis
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diagnosis*,
drug therapy,
metabolism Administration, Topical Anti-Bacterial Agents / therapeutic use Anti-Inflammatory Agents / therapeutic use Antigens, CD1 / metabolism Child, Preschool Diagnosis, Differential Exanthema / etiology Glucocorticoids Humans Immunoenzyme Techniques Langerhans Cells / metabolism, pathology Lichenoid Eruptions / diagnosis*, drug therapy Male Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents; 0/Antigens, CD1; 0/Glucocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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