Document Detail

Ghrelin stimulates growth hormone secretion and food intake in aged rats.
MedLine Citation:
PMID:  17109935     Owner:  NLM     Status:  MEDLINE    
Age-related decreases in energy expenditure have been associated with the loss of skeletal muscle and decline of food intake, possibly through a mechanism involving changes of growth hormone (GH) secretion and feeding behavior. Age-related declines of growth hormone secretion and food intake have been termed the somatopause and anorexia of ageing, respectively. Ghrelin, a 28-amino-acid peptide, was isolated from human and rat stomachs as an endogenous ligand of growth hormone secretagogue receptor. Ghrelin stimulates growth hormone release and food intake when peripherally administered to rodents and humans. Here, we investigate the relationship between age-related decline of growth hormone secretion and/or food intake and ghrelin function. Ghrelin (10 nmol/kg body weight) was administered intravenously to male 3-, 12-, 24-and 27-month-old Long-Evans rats, after which growth hormone concentrations and 2 h food intake were measured. An intravenous administration of ghrelin to rats increased food intake in all generations. In addition, to orexigenic effect by ghrelin, intravenous administration of ghrelin elicited a marked increase in plasma GH levels, with the peak occurring 15 min after administration. These findings suggest that the aged rats maintain the reactivity to administered exogenous ghrelin.
Koji Toshinai; Muhtashan S Mondal; Takuya Shimbara; Hideki Yamaguchi; Yukari Date; Kenji Kangawa; Masamitsu Nakazato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-15
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  128     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-05-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  182-6     Citation Subset:  IM    
Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
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MeSH Terms
Age Factors
Aging / drug effects,  physiology*
Body Weight / drug effects
Eating / drug effects*
Growth Hormone / secretion*
Peptide Hormones / pharmacology*
Rats, Inbred LEC
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones; 9002-72-6/Growth Hormone

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