| Ghrelin stimulates growth hormone secretion and food intake in aged rats. | |
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MedLine Citation:
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PMID: 17109935 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Age-related decreases in energy expenditure have been associated with the loss of skeletal muscle and decline of food intake, possibly through a mechanism involving changes of growth hormone (GH) secretion and feeding behavior. Age-related declines of growth hormone secretion and food intake have been termed the somatopause and anorexia of ageing, respectively. Ghrelin, a 28-amino-acid peptide, was isolated from human and rat stomachs as an endogenous ligand of growth hormone secretagogue receptor. Ghrelin stimulates growth hormone release and food intake when peripherally administered to rodents and humans. Here, we investigate the relationship between age-related decline of growth hormone secretion and/or food intake and ghrelin function. Ghrelin (10 nmol/kg body weight) was administered intravenously to male 3-, 12-, 24-and 27-month-old Long-Evans rats, after which growth hormone concentrations and 2 h food intake were measured. An intravenous administration of ghrelin to rats increased food intake in all generations. In addition, to orexigenic effect by ghrelin, intravenous administration of ghrelin elicited a marked increase in plasma GH levels, with the peak occurring 15 min after administration. These findings suggest that the aged rats maintain the reactivity to administered exogenous ghrelin. |
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Authors:
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Koji Toshinai; Muhtashan S Mondal; Takuya Shimbara; Hideki Yamaguchi; Yukari Date; Kenji Kangawa; Masamitsu Nakazato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-11-15 |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 128 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-23 Completed Date: 2007-05-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 182-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging / drug effects, physiology* Animals Body Weight / drug effects Eating / drug effects* Ghrelin Growth Hormone / secretion* Male Peptide Hormones / pharmacology* Rats Rats, Inbred LEC |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Peptide Hormones; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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