| Ghrelin, the same peptide for different functions: player or bystander? | |
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MedLine Citation:
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PMID: 16112276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ghrelin is a recently discovered brain-gut peptide with two main physiological actions: growth hormone secretagogue activity and food intake inducer. Although its production is prevalently gastric, ghrelin is widely expressed in several tissues, where it might therefore act as a paracrine or autocrine factor. It is becoming clear that ghrelin is much more than a simple growth hormone secretagogue. In addition to its formerly envisaged role, ghrelin has other activities including stimulation of pituitary hormones secretion, modulation of food intake and control of energy metabolism, regulation of gastric and pancreatic activity, and cardiovascular and hemodynamic activities. In addition, modulation of cartilage and bone homeostasis, sleep and behavioral influences, and modulation of the immune system, as well as effects on cell proliferation, are other relevant actions of ghrelin. Thus, the peptide appears to be an important component of an integrated multifaceted regulatory system. In this review, we summarize several aspects of ghrelin biology and attempt to inform the reader with information regarding unexpected functions of this gastric peptide. |
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Authors:
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Francisca Lago; José Ramón Gonzalez-Juanatey; Felipe F Casanueva; Juan Gómez-Reino; Carlos Dieguez; Oreste Gualillo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Vitamins and hormones Volume: 71 ISSN: 0083-6729 ISO Abbreviation: Vitam. Horm. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-08-22 Completed Date: 2005-11-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413601 Medline TA: Vitam Horm Country: United States |
Other Details:
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Languages: eng Pagination: 405-32 Citation Subset: IM |
Affiliation:
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Santiago University Clinical Hospital, Research Area, Molecular and Cellular Cardiology Laboratory 1, 15705 Santiago de Compostela, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acylation Amino Acid Sequence Animals Appetite Behavior Bone and Bones Cardiovascular System Cartilage Cell Division Energy Metabolism Ghrelin Growth Hormone / secretion Homeostasis Humans Immunity Mice Mice, Knockout Molecular Sequence Data Pancreas / physiology Peptide Hormones / chemistry, deficiency, physiology* Receptors, G-Protein-Coupled / deficiency Receptors, Ghrelin Sleep Stomach / physiology Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Peptide Hormones; 0/Receptors, G-Protein-Coupled; 0/Receptors, Ghrelin; 9002-72-6/Growth Hormone |
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