| Ghrelin and the regulation of food intake and energy balance. | |
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MedLine Citation:
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PMID: 14993401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach and is released in response to acute and chronic changes in nutritional state. In addition to having a powerful effect on the secretion of growth hormone, ghrelin stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. Thus, it is interesting to note that the stomach may play an important role in not only digestion but also pituitary growth hormone release and central feeding regulation. We summarize recent findings on the integration of ghrelin into neuroendocrine networks that regulate food intake and energy balance. |
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Authors:
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Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Molecular interventions Volume: 2 ISSN: 1534-0384 ISO Abbreviation: Mol. Interv. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2004-03-02 Completed Date: 2004-04-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101093789 Medline TA: Mol Interv Country: United States |
Other Details:
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Languages: eng Pagination: 494-503 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Energy Metabolism* Feeding Behavior* Ghrelin Growth Hormone / secretion* Human Growth Hormone / secretion* Humans Hypothalamus / physiology* Peptide Hormones / physiology* Receptors, G-Protein-Coupled / metabolism Receptors, Ghrelin |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Peptide Hormones; 0/Receptors, G-Protein-Coupled; 0/Receptors, Ghrelin; 12629-01-5/Human Growth Hormone; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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