Document Detail

Ghrelin and the regulation of food intake and energy balance.
MedLine Citation:
PMID:  14993401     Owner:  NLM     Status:  MEDLINE    
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach and is released in response to acute and chronic changes in nutritional state. In addition to having a powerful effect on the secretion of growth hormone, ghrelin stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. Thus, it is interesting to note that the stomach may play an important role in not only digestion but also pituitary growth hormone release and central feeding regulation. We summarize recent findings on the integration of ghrelin into neuroendocrine networks that regulate food intake and energy balance.
Hiroshi Hosoda; Masayasu Kojima; Kenji Kangawa
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular interventions     Volume:  2     ISSN:  1534-0384     ISO Abbreviation:  Mol. Interv.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2004-03-02     Completed Date:  2004-04-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101093789     Medline TA:  Mol Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  494-503     Citation Subset:  IM    
Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka 565-8565, Japan.
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MeSH Terms
Energy Metabolism*
Feeding Behavior*
Growth Hormone / secretion*
Human Growth Hormone / secretion*
Hypothalamus / physiology*
Peptide Hormones / physiology*
Receptors, G-Protein-Coupled / metabolism
Receptors, Ghrelin
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones; 0/Receptors, G-Protein-Coupled; 0/Receptors, Ghrelin; 12629-01-5/Human Growth Hormone; 9002-72-6/Growth Hormone

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