Document Detail


Ghrelin reduces hypertonic saline intake in a variety of natriorexigenic conditions.
MedLine Citation:
PMID:  21784787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ghrelin is a gut peptide that has been studied extensively for its role in food intake and energy balance. More recent studies show that ghrelin reduces water intake in rats and some non-mammalian species. Despite the importance of the regulation of NaCl intake in body fluid homeostasis, the effects of ghrelin on saline intake have not been investigated. Accordingly, we tested the effect of ghrelin on water and 1.8% NaCl intake in two-bottle test conditions with the following five stimuli that increase hypertonic saline intake: central angiotensin II administration; 24 h fluid deprivation; water deprivation followed by partial rehydration; dietary sodium deficiency; and polyethylene glycol administration combined with dietary sodium deficiency. We found that ghrelin attenuated saline intake stimulated by angiotensin II, by water deprivation followed by partial rehydration and by dietary sodium deficiency. We did not detect an effect of ghrelin on saline intake after 24 h fluid deprivation without partial rehydration or after the combination of polyethylene glycol and dietary sodium deficiency. The finding that ghrelin reduced hypertonic saline intake in some, but not all, natriorexigenic conditions mirrors the previously published findings that in one-bottle tests of drinking, ghrelin reduces water intake in only some conditions. The results provide evidence for a new role for ghrelin in the regulation of body fluid homeostasis.
Authors:
Elizabeth G Mietlicki; Derek Daniels
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-07-22
Journal Detail:
Title:  Experimental physiology     Volume:  96     ISSN:  1469-445X     ISO Abbreviation:  Exp. Physiol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-14     Completed Date:  2012-01-11     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1072-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / pharmacology
Animals
Drinking / drug effects*
Food Deprivation / physiology
Ghrelin / pharmacology*
Hypovolemia / chemically induced,  physiopathology
Male
Rats
Rats, Sprague-Dawley
Saline Solution, Hypertonic* / pharmacology
Sodium / deficiency
Water Deprivation / physiology
Grant Support
ID/Acronym/Agency:
DK-73800/DK/NIDDK NIH HHS; HL-91911/HL/NHLBI NIH HHS; K01 DK073800/DK/NIDDK NIH HHS; K01 DK073800-05/DK/NIDDK NIH HHS; R01 HL091911/HL/NHLBI NIH HHS; R01 HL091911-03/HL/NHLBI NIH HHS; R01 HL091911-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Saline Solution, Hypertonic; 11128-99-7/Angiotensin II; 9NEZ333N27/Sodium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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