| Ghrelin reduces hepatic mitochondrial fatty acid beta oxidation. | |
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MedLine Citation:
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PMID: 17556859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ghrelin is a 28-amino-acid peptide secreted during starvation by gastric cells. Ghrelin physiologically induces food intake and seems to alter lipid and glucid metabolism in several tissues such as adipose tissue and liver. Liver has a key position in lipid metabolism as it allows the metabolic orientation of fatty acids between oxidation and esterification. We investigated the effects of peripheral ghrelin administration on 2 crucial parameters of fatty acid oxidation: the levocarnitine (L-carnitine)-dependent entry of the fatty acids in the mitochondria and the mitochondrial fatty acid oxidation. Ghrelin was either given to rats prior to the hepatocyte preparation and culture or used to treat hepatocytes prepared from control animals. Direct incubation of ghrelin to raw hepatocytes did not induce any change in the studied parameters. In hepatocytes prepared from 3 nmol ghrelin-treated rats, a 44% reduction of the mitochondrial fatty acid oxidation while no alteration of the L-carnitine-related parameters were observed. These results suggested (a) that ghrelin has no direct effect on liver, and (b) that when administrated to a whole organism, ghrelin may alter the lipid metabolism and the energy balance through a marked decrease in liver fatty acid oxidation. |
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Authors:
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C Rigault; F Le Borgne; B Georges; J Demarquoy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 30 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-06-08 Completed Date: 2007-07-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: RC4-8 Citation Subset: IM |
Affiliation:
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INSERM, Faculty of Sciences Gabriel, Metabolic and Nutritional Biochemics (LBMN), University of Burgundy, Dijon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / drug effects Carnitine / pharmacology Cells, Cultured Energy Metabolism / drug effects Fatty Acids / metabolism* Ghrelin Lipid Metabolism / drug effects* Mitochondria, Liver / drug effects*, metabolism Oxidation-Reduction / drug effects Peptide Hormones / pharmacology* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Ghrelin; 0/Peptide Hormones; 541-15-1/Carnitine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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