Document Detail

Ghrelin reduces hepatic mitochondrial fatty acid beta oxidation.
MedLine Citation:
PMID:  17556859     Owner:  NLM     Status:  MEDLINE    
Ghrelin is a 28-amino-acid peptide secreted during starvation by gastric cells. Ghrelin physiologically induces food intake and seems to alter lipid and glucid metabolism in several tissues such as adipose tissue and liver. Liver has a key position in lipid metabolism as it allows the metabolic orientation of fatty acids between oxidation and esterification. We investigated the effects of peripheral ghrelin administration on 2 crucial parameters of fatty acid oxidation: the levocarnitine (L-carnitine)-dependent entry of the fatty acids in the mitochondria and the mitochondrial fatty acid oxidation. Ghrelin was either given to rats prior to the hepatocyte preparation and culture or used to treat hepatocytes prepared from control animals. Direct incubation of ghrelin to raw hepatocytes did not induce any change in the studied parameters. In hepatocytes prepared from 3 nmol ghrelin-treated rats, a 44% reduction of the mitochondrial fatty acid oxidation while no alteration of the L-carnitine-related parameters were observed. These results suggested (a) that ghrelin has no direct effect on liver, and (b) that when administrated to a whole organism, ghrelin may alter the lipid metabolism and the energy balance through a marked decrease in liver fatty acid oxidation.
C Rigault; F Le Borgne; B Georges; J Demarquoy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  30     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-06-08     Completed Date:  2007-07-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  RC4-8     Citation Subset:  IM    
INSERM, Faculty of Sciences Gabriel, Metabolic and Nutritional Biochemics (LBMN), University of Burgundy, Dijon, France.
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MeSH Terms
Biological Transport / drug effects
Carnitine / pharmacology
Cells, Cultured
Energy Metabolism / drug effects
Fatty Acids / metabolism*
Lipid Metabolism / drug effects*
Mitochondria, Liver / drug effects*,  metabolism
Oxidation-Reduction / drug effects
Peptide Hormones / pharmacology*
Rats, Wistar
Reg. No./Substance:
0/Fatty Acids; 0/Ghrelin; 0/Peptide Hormones; 541-15-1/Carnitine

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