Document Detail

Ghrelin promotes antioxidant enzyme activity and reduces lipid peroxidation in the rat ovary.
MedLine Citation:
PMID:  20171996     Owner:  NLM     Status:  MEDLINE    
Antioxidant properties of ghrelin have been recently reported on various oxidative stresses in limited tissues. This study was set to examine the possible antioxidative effects of ghrelin in rat ovarian tissue. Twenty eight female adult Wistar rats were randomly allocated into control and treatment groups. Treatment group (n=14) received 2nmol of ghrelin as subcutaneous injection for 14 consecutive days or vehicle (physiological saline) to the control rats. The animals from both groups were equally killed on days 9 and 14 after beginning of ghrelin injection (n=7 from each group on each day) and their ovaries were taken for later antioxidant enzyme activity assays as well as measurement of glutathione content and thiobarbituric acid reactive substances (TBARS) level. Superoxide dismutase activity was significantly higher on days 9 (P<0.05) and 14 (P<0.01) in the treated group compared to the control rats. By contrast, lipid peroxidation, as TBARS value, reduced significantly on both experimental days in the ghrelin-exposed animals (P<0.05). Although, the mean activity of catalase and glutathione content was greater in the treated rats, however, the differences were not statistically significant. Slight changes occurred in glutathione peroxidase activity during the experimental period and there were no differences either on day 9 or on day 14 between groups. In conclusion, the results of the present investigation indicate for the first time the novel evidence of antioxidant properties of ghrelin in the rat ovary.
Arash Kheradmand; Masoud Alirezaei; Mahdi Birjandi
Related Documents :
10993486 - 7-hydroperoxycholesterol as a marker of oxidative stress in rat kidney induced by paraq...
16253326 - Differentiating copper and arsenic toxicity using biochemical biomarkers in asellus aqu...
7374796 - Lack of in vivo lipid peroxidation in experimental paraquat poisoning.
17006976 - Hypolipidaemic activity of aqueous ocimum basilicum extract in acute hyperlipidaemia in...
1267436 - Effect of cephalothin on renal cortical concentrations of gentamicin in rats.
18609716 - 1,25-dihydroxyvitamin d(3) regulates lps-induced cytokine production and reduces mortal...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-19
Journal Detail:
Title:  Regulatory peptides     Volume:  162     ISSN:  1873-1686     ISO Abbreviation:  Regul. Pept.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Clinical Sciences, School of Veterinary Medicine, University of Lorestan, P.O. Box: 465, Khorram Abad, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antioxidants / pharmacology*
Catalase / metabolism*
Ghrelin / pharmacology*
Glutathione / metabolism
Glutathione Peroxidase / metabolism*
Lipid Peroxidation / drug effects*
Ovary / drug effects*,  enzymology,  metabolism
Superoxide Dismutase / metabolism*
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Ghrelin; 0/Thiobarbituric Acid Reactive Substances; 70-18-8/Glutathione; EC; EC Peroxidase; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Rikkunshito and 5-HT2C antagonist improves cisplatin-induced anorexia via hypothalamic ghrelin inter...
Next Document:  Comparative Analysis of Fecal DNA Extraction Methods with Phylogenetic Microarray: Effective Recover...