Document Detail


Ghrelin promotes antioxidant enzyme activity and reduces lipid peroxidation in the rat ovary.
MedLine Citation:
PMID:  20171996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antioxidant properties of ghrelin have been recently reported on various oxidative stresses in limited tissues. This study was set to examine the possible antioxidative effects of ghrelin in rat ovarian tissue. Twenty eight female adult Wistar rats were randomly allocated into control and treatment groups. Treatment group (n=14) received 2nmol of ghrelin as subcutaneous injection for 14 consecutive days or vehicle (physiological saline) to the control rats. The animals from both groups were equally killed on days 9 and 14 after beginning of ghrelin injection (n=7 from each group on each day) and their ovaries were taken for later antioxidant enzyme activity assays as well as measurement of glutathione content and thiobarbituric acid reactive substances (TBARS) level. Superoxide dismutase activity was significantly higher on days 9 (P<0.05) and 14 (P<0.01) in the treated group compared to the control rats. By contrast, lipid peroxidation, as TBARS value, reduced significantly on both experimental days in the ghrelin-exposed animals (P<0.05). Although, the mean activity of catalase and glutathione content was greater in the treated rats, however, the differences were not statistically significant. Slight changes occurred in glutathione peroxidase activity during the experimental period and there were no differences either on day 9 or on day 14 between groups. In conclusion, the results of the present investigation indicate for the first time the novel evidence of antioxidant properties of ghrelin in the rat ovary.
Authors:
Arash Kheradmand; Masoud Alirezaei; Mahdi Birjandi
Related Documents :
22771386 - Neonatal caffeine treatment up-regulates adenosine receptors in brainstem and hypothala...
20358346 - Protective effects of caffeic acid phenethyl ester on iron-induced liver damage in rats.
12030376 - Early changes in myocardial antioxidant enzymes in rats treated with adriamycin.
2917406 - Lipid peroxidation in developing fetal guinea pig brain during normoxia and hypoxia.
15481806 - "ultrashort" control of hypothalamic hormones secretion: a brief history.
8023966 - Endogenous renal dopamine production regulates phosphate excretion.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-19
Journal Detail:
Title:  Regulatory peptides     Volume:  162     ISSN:  1873-1686     ISO Abbreviation:  Regul. Pept.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Clinical Sciences, School of Veterinary Medicine, University of Lorestan, P.O. Box: 465, Khorram Abad, Iran. arashkheradmand@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Catalase / metabolism*
Female
Ghrelin / pharmacology*
Glutathione / metabolism
Glutathione Peroxidase / metabolism*
Lipid Peroxidation / drug effects*
Ovary / drug effects*,  enzymology,  metabolism
Rats
Superoxide Dismutase / metabolism*
Thiobarbituric Acid Reactive Substances / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Ghrelin; 0/Thiobarbituric Acid Reactive Substances; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rikkunshito and 5-HT2C antagonist improves cisplatin-induced anorexia via hypothalamic ghrelin inter...
Next Document:  Comparative Analysis of Fecal DNA Extraction Methods with Phylogenetic Microarray: Effective Recover...