Document Detail

Ghrelin prevents neuronal apoptosis and cognitive impairments in sepsis-associated encephalopathy.
MedLine Citation:
PMID:  22027512     Owner:  NLM     Status:  MEDLINE    
The present study explored the effect of ghrelin in protecting neurons from apoptosis in sepsis-associated encephalopathy. Ghrelin (100 nM) increased the cell viability treated with lipopolysaccharide (1.0 μg/ml, 24 h). The expression of p-Akt and Bcl-2 were decreased and caspase-3 increased both in lipopolysaccharide-treated primary hippocampal cultures and in the cecal ligation and perforation model, which were alleviated in the presence of ghrelin. In vitro, the protecting effect of ghrelin was almost abolished by the Akt inhibitor, SH-5. In vivo, the cecal ligation and perforation rats exhibited emotional, learning, and memory deficits. Administration of ghrelin attenuated the cognitive deficits significantly. These results indicate that ghrelin alleviates neuronal apoptosis and subsequent cognitive impairments in sepsis-associated encephalopathy through the Akt pathway.
Guobin Wang; Wenyuan Wang; Jinning Zhao; Yunlan Ni; Xinping Zhou; Weifang Zhang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication    
Journal Detail:
Title:  Neuroreport     Volume:  22     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-17     Completed Date:  2012-03-13     Revised Date:  2012-05-03    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  959-64     Citation Subset:  IM    
Department of Surgical Intensive Care Unit, the First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, People's Republic of China.
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MeSH Terms
Analysis of Variance
Apoptosis / drug effects
Avoidance Learning / drug effects
Brain Diseases / etiology*,  prevention & control*
Cell Survival
Cells, Cultured
Cognition Disorders / etiology*,  prevention & control*
Disease Models, Animal
Embryo, Mammalian
Exploratory Behavior / drug effects
Gene Expression Regulation / drug effects
Ghrelin / administration & dosage*
Hippocampus / cytology
Ligation / methods
Lipopolysaccharides / pharmacology
Neurons / drug effects
Oncogene Protein v-akt / metabolism
Rats, Sprague-Dawley
Sepsis / complications*,  drug therapy
Reg. No./Substance:
0/Ghrelin; 0/Lipopolysaccharides; EC Protein v-akt
Retraction In:
Neuroreport. 2012 Apr 18;23(6):405   [PMID:  22456190 ]

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