| Ghrelin and peptide YY (PYY) profiles in gastrointestinal tissues and the circulation of the rat during pregnancy and lactation. | |
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MedLine Citation:
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PMID: 19778563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma and tissue profiles of gastrointestinal hormones ghrelin and peptide YY (PYY) were investigated in different female rat reproductive states. Neither plasma nor tissue ghrelin concentrations were suppressed during pregnancy despite elevated leptin. The highest concentrations of stomach ghrelin were measured in late pregnancy. PYY concentrations in plasma, descending colon and rectum tissues were increased (P<0.001) throughout pregnancy and lactation. PYY peaked at day 5 of lactation in plasma, as well as descending colon and rectum tissues (proestrus vs day 5 of lactation: 25+/-3.0 pmol/l vs 55+/-8.0 pmol/l; 85+/-4.5 pmol/g wwt vs 418+/-45.0 pmol/g wwt; 23+/-3.0 pmol/g wwt vs 78+/-9.1 pmol/g wwt). This PYY peak was temporally associated with the luteinizing hormone peak on day 1 of lactation. Following weaning, dam adiposity and plasma leptin increased whereas ghrelin stomach peptide decreased. Relative PYY concentrations in the tissues of the gut varied in the different states suggesting regional alterations taking place in the colon. The ascending colon produced the highest concentrations in non-pregnant rats, the descending colon the highest concentrations during lactation with the pregnant rats and the dams postweaning in a transition state between. It is unclear what role the increased PYY in various tissues observed has during pregnancy and lactation as it would be expected to be reduced in these states of greatly increased appetite. PYY may have an influence on maternal dietary adaptation, intestinal hypertrophy and weight gain during pregnancy and lactation although it is still unclear precisely how it acts. |
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Authors:
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Victoria J Taylor; Michael Patterson; Mohammed A Ghatei; Stephen R Bloom; Catherine A Wilson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-22 |
Journal Detail:
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Title: Peptides Volume: 30 ISSN: 1873-5169 ISO Abbreviation: Peptides Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-25 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 2213-20 Citation Subset: IM |
Affiliation:
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Department of Metabolic Medicine, Faculty of Medicine, Imperial College London, Hammersmith Hospital, 6th Floor, Commonwealth Building, Du Cane Road, London W12 0NN, UK. v.taylor@open.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Colon, Ascending / metabolism Colon, Descending / metabolism Female Ghrelin / blood*, metabolism* Ileum / metabolism Lactation / blood*, metabolism* Leptin / blood Luteinizing Hormone / blood Peptide YY / blood*, metabolism* Pregnancy Progesterone / blood Prolactin / blood Rats Rectum / metabolism Stomach / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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072643/Z/03/Z),//Wellcome Trust; G7811974//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Leptin; 106388-42-5/Peptide YY; 57-83-0/Progesterone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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