Document Detail

Ghrelin ovarian cell expression in patients with polycystic ovary syndrome: an immunohistochemical evaluation.
MedLine Citation:
PMID:  17163351     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The influence of ghrelin on different organs has been studied recently, e.g. in the regulation of pituitary hormone release, regulation of energy homeostasis, glucose metabolism and insulin secretion, cell proliferation, and reproductive function. However, the etiology of polycystic ovary syndrome has not been fully explained. The aim of our study was to estimate the presence of ghrelin in polycystic ovaries cells and evaluation of the relationship between ghrelin occurrence and cells proliferation. METHODS: In the present work we have compared ten polycystic ovaries with ovaries without pathology as the control group. We used immunohistochemical method to detect ghrelin. The cells proliferation was evaluated by Ki 67 proliferation index. RESULTS: Ghrelin immunostaining was demonstrated in cytoplasm of ovarian secondary interstitial cells and in atretic corpus luteum. The cell nuclei were ghrelin positive in granulosa, theca layers of follicular cyst in both groups as well as in luteal cells of young corpus luteum in healthy ovaries. Ki 67 immunostaining was observed in granulosa and theca layers of follicular cyst in polycystic and healthy ovaries. CONCLUSIONS: It is possible that local ghrelin expression plays an important role in the direct control of ovarian development and function and ghrelin may participate in patomechanism of PCOS.
H Komarowska; R Waśko; K Iwanik; P Majewski; L Rafińska; A Warenik-Szymankiewicz; J Sowiński
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  38     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-13     Completed Date:  2007-03-19     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  783-8     Citation Subset:  IM    
Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland.
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MeSH Terms
Cell Proliferation
Gene Expression
Ki-67 Antigen / metabolism
Middle Aged
Ovary / metabolism*,  pathology
Peptide Hormones / metabolism*
Polycystic Ovary Syndrome / metabolism*,  pathology
Reg. No./Substance:
0/Ghrelin; 0/Ki-67 Antigen; 0/Peptide Hormones

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