Document Detail

Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract.
MedLine Citation:
PMID:  12482728     Owner:  NLM     Status:  MEDLINE    
Recent identification of novel appetite-regulating hormones has revealed the complex interactions between these humoral factors in the regulation of feeding behavior in mammals. One such hormone is ghrelin, which is a natural ligand of the orphan growth hormone secretagogue receptor. Ghrelin was first purified from rat stomach and is able to stimulate growth hormone release from pituitary cells. Ghrelin is a peptide of 28 amino acids, in which Ser3 is modified by an n-octanoic acid. This modification is essential for the activity of ghrelin. The peptide regulates food intake by acting on the hypothalamic arcuate nucleus, which is a region known to control food intake. Thus, gastric ghrelin is an endogenous regulator of feeding behavior that is found in both peripheral tissues and the central nervous system.
Masayasu Kojima; Kenji Kangawa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  2     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-16     Completed Date:  2003-08-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  665-8     Citation Subset:  IM    
Molecular Genetics, Institute of Life Science, Kurume University, Kurume, 839-0861, Fukuoka, Japan.
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MeSH Terms
Amino Acid Sequence
Appetite / drug effects,  physiology
Arcuate Nucleus / drug effects
Digestive System / drug effects,  innervation,  metabolism*,  secretion
Peptide Hormones / analysis,  chemistry,  metabolism*,  pharmacology
Signal Transduction* / drug effects
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones

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