Document Detail


Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract.
MedLine Citation:
PMID:  12482728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent identification of novel appetite-regulating hormones has revealed the complex interactions between these humoral factors in the regulation of feeding behavior in mammals. One such hormone is ghrelin, which is a natural ligand of the orphan growth hormone secretagogue receptor. Ghrelin was first purified from rat stomach and is able to stimulate growth hormone release from pituitary cells. Ghrelin is a peptide of 28 amino acids, in which Ser3 is modified by an n-octanoic acid. This modification is essential for the activity of ghrelin. The peptide regulates food intake by acting on the hypothalamic arcuate nucleus, which is a region known to control food intake. Thus, gastric ghrelin is an endogenous regulator of feeding behavior that is found in both peripheral tissues and the central nervous system.
Authors:
Masayasu Kojima; Kenji Kangawa
Related Documents :
16787228 - Npy receptors as drug targets for the central regulation of body weight.
11181518 - Immediate and prolonged patterns of agouti-related peptide-(83--132)-induced c-fos acti...
18786538 - Anorexigenic effects of central neuropeptide k are associated with hypothalamic changes...
17082808 - The role of oxyntomodulin and peptide tyrosine-tyrosine (pyy) in appetite control.
22318448 - Heating affects structure, enterocyte adsorption and signalling, as well as immunogenic...
8354578 - Biological monitoring of occupational exposure to n-hexane by measurement of urinary 2,...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  2     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-16     Completed Date:  2003-08-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  665-8     Citation Subset:  IM    
Affiliation:
Molecular Genetics, Institute of Life Science, Kurume University, Kurume, 839-0861, Fukuoka, Japan. mkojima@lsi.kurume-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Appetite / drug effects,  physiology
Arcuate Nucleus / drug effects
Digestive System / drug effects,  innervation,  metabolism*,  secretion
Ghrelin
Humans
Peptide Hormones / analysis,  chemistry,  metabolism*,  pharmacology
Signal Transduction* / drug effects
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Controlling the excitability of IPANs: a possible route to therapeutics.
Next Document:  Neuroimmune and epithelial interactions in intestinal inflammation.