Document Detail

Ghrelin and motilin concentration in colicky infants.
MedLine Citation:
PMID:  16754557     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate serum ghrelin and motilin concentration in infants with infantile colic. METHODS: A case-control study was conducted on fasting blood venous samples obtained from 18 infants with infantile colic and 20 healthy infants to measure ghrelin (RIA test) and motilin (RIA test). RESULTS: Colicky infants showed higher ghrelin serum levels (2534.2 +/- 600.0 pg/ml; ln 7.8 +/- 0.2) than controls (2126.1 +/- 281.3 pg/ml; ln 7.6 +/- 0.1) (p = 0.011). Serum motilin concentration was significantly higher in colicky infants (94.6 +/- 23.2 pmol/l) than in controls (64.1 +/- 30.1 pmol/l) (p = 0.001). Motilin concentrations were higher in formula-fed colicky infants (104.5 +/- 20.4 pmol/l) than in breastfed ones (82.2 +/- 21.3 pmol/l) (p = 0.038). CONCLUSION: Our finding shows that ghrelin and motilin concentrations are higher in infants with colic than in controls, supporting an organicistic aetiopathogenesis of this disorder. Furthermore, the role of ghrelin on gastrointestinal motility may open new doors to better understand the aetiology of infantile colic.
Francesco Savino; Erica Clara Grassino; Carla Guidi; Roberto Oggero; Leandra Silvestro; Roberto Miniero
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  95     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-06     Completed Date:  2007-04-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  738-41     Citation Subset:  IM    
Department of Paediatrics, Regina Margherita Hospital, Turin University, Turin, Italy.
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MeSH Terms
Colic / blood*
Infant, Newborn
Motilin / blood*
Peptide Hormones / blood*
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones; 52906-92-0/Motilin

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