Document Detail

Ghrelin: a metabolic signal affecting the reproductive system.
MedLine Citation:
PMID:  19297235     Owner:  NLM     Status:  MEDLINE    
Ghrelin, an acylated 28 amino acid gastric peptide, was isolated from the stomach as an endogenous ligand for growth hormone (GH) secretagogue receptor in 1999. Circulating ghrelin is mainly produced by specific cells in the stomach's oxyntic glands. Ghrelin potently stimulates GH release and food intake and exhibits diverse effects, including ones on glucose metabolism and on secretion and motility of the gastrointestinal tract. Besides these effects on food intake and energy homeostasis, ghrelin is also involved in controlling reproductive functions, and a role for it as a novel regulator of the hypothalamic-pituitary gonadal axis is clearly emerging. We review recent ghrelin research with emphasis on its roles in the reproductive axis.
Teresa Lorenzi; Rosaria Meli; Daniela Marzioni; Manrico Morroni; Alessandra Baragli; Mario Castellucci; Oreste Gualillo; Giampiero Muccioli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-17
Journal Detail:
Title:  Cytokine & growth factor reviews     Volume:  20     ISSN:  1879-0305     ISO Abbreviation:  Cytokine Growth Factor Rev.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-06-05     Revised Date:  2009-09-01    
Medline Journal Info:
Nlm Unique ID:  9612306     Medline TA:  Cytokine Growth Factor Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-52     Citation Subset:  IM    
Department of Molecular Pathology and Innovative Therapies-Anatomy and Cell Biology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60020 Ancona, Italy.
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MeSH Terms
Eating / physiology
Energy Metabolism / physiology
Ghrelin / physiology*
Glucose / metabolism
Homeostasis / physiology
Hypothalamo-Hypophyseal System / drug effects,  physiology
Receptors, Ghrelin / physiology
Reproduction / drug effects,  physiology*
Signal Transduction / physiology
Testis / metabolism
Reg. No./Substance:
0/Ghrelin; 0/Receptors, Ghrelin; 50-99-7/Glucose
Comment In:
Cytokine Growth Factor Rev. 2009 Aug;20(4):339-40   [PMID:  19646912 ]

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