Document Detail


Ghrelin: a metabolic signal affecting the reproductive system.
MedLine Citation:
PMID:  19297235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ghrelin, an acylated 28 amino acid gastric peptide, was isolated from the stomach as an endogenous ligand for growth hormone (GH) secretagogue receptor in 1999. Circulating ghrelin is mainly produced by specific cells in the stomach's oxyntic glands. Ghrelin potently stimulates GH release and food intake and exhibits diverse effects, including ones on glucose metabolism and on secretion and motility of the gastrointestinal tract. Besides these effects on food intake and energy homeostasis, ghrelin is also involved in controlling reproductive functions, and a role for it as a novel regulator of the hypothalamic-pituitary gonadal axis is clearly emerging. We review recent ghrelin research with emphasis on its roles in the reproductive axis.
Authors:
Teresa Lorenzi; Rosaria Meli; Daniela Marzioni; Manrico Morroni; Alessandra Baragli; Mario Castellucci; Oreste Gualillo; Giampiero Muccioli
Related Documents :
10880245 - Selectivity release of the type ii decoy il-1 receptor.
20825365 - Neuroadipology: a novel component of neuroendocrinology.
15215775 - Clarifying concepts about macronutrients' effects on satiation and satiety.
17132825 - Hypothalamic mapping of orexigenic action and fos-like immunoreactivity following relax...
3413195 - The effects of d-fenfluramine on saccharin intake and preference, and on food and water...
18712335 - Chemically mediated burrow recognition in the mexican tarantula brachypelma vagans female.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-17
Journal Detail:
Title:  Cytokine & growth factor reviews     Volume:  20     ISSN:  1879-0305     ISO Abbreviation:  Cytokine Growth Factor Rev.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-06-05     Revised Date:  2009-09-01    
Medline Journal Info:
Nlm Unique ID:  9612306     Medline TA:  Cytokine Growth Factor Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-52     Citation Subset:  IM    
Affiliation:
Department of Molecular Pathology and Innovative Therapies-Anatomy and Cell Biology, Faculty of Medicine, Polytechnic University of Marche, Via Tronto 10/a, 60020 Ancona, Italy. teresalorenzi@yahoo.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Eating / physiology
Energy Metabolism / physiology
Female
Ghrelin / physiology*
Glucose / metabolism
Homeostasis / physiology
Humans
Hypothalamo-Hypophyseal System / drug effects,  physiology
Male
Receptors, Ghrelin / physiology
Reproduction / drug effects,  physiology*
Signal Transduction / physiology
Testis / metabolism
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Receptors, Ghrelin; 50-99-7/Glucose
Comments/Corrections
Comment In:
Cytokine Growth Factor Rev. 2009 Aug;20(4):339-40   [PMID:  19646912 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Examining the interaction between food outlets and outdoor food advertisements with primary school f...
Next Document:  Enhancing the approach to selecting eyewear (EASE): A multi-centre, practice-based study into the ef...