Document Detail

Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats.
MedLine Citation:
PMID:  16631138     Owner:  NLM     Status:  MEDLINE    
Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and a well-characterized food intake regulatory peptide. Hypothalamic ghrelin-, neuropeptide Y (NPY)-, and orexin-containing neurons form a feeding regulatory circuit. Orexins and NPY are also implicated in sleep-wake regulation. Sleep responses and motor activity after central administration of 0.2, 1, or 5 microg ghrelin in free-feeding rats as well as in feeding-restricted rats (1 microg dose) were determined. Food and water intake and behavioral responses after the light onset injection of saline or 1 microg ghrelin were also recorded. Light onset injection of ghrelin suppressed non-rapid-eye-movement sleep (NREMS) and rapid-eye-movement sleep (REMS) for 2 h. In the first hour, ghrelin induced increases in behavioral activity including feeding, exploring, and grooming and stimulated food and water intake. Ghrelin administration at dark onset also elicited NREMS and REMS suppression in hours 1 and 2, but the effect was not as marked as that, which occurred in the light period. In hours 3-12, a secondary NREMS increase was observed after some doses of ghrelin. In the feeding-restricted rats, ghrelin suppressed NREMS in hours 1 and 2 and REMS in hours 3-12. Data are consistent with the notion that ghrelin has a role in the integration of feeding, metabolism, and sleep regulation.
E Szentirmai; I Hajdu; F Obal; James M Krueger
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2006-05-02
Journal Detail:
Title:  Brain research     Volume:  1088     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-24     Completed Date:  2006-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  131-40     Citation Subset:  IM    
Department of Physiology, A. Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, Szeged, Hungary.
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MeSH Terms
Analysis of Variance
Behavior, Animal
Circadian Rhythm / physiology
Dose-Response Relationship, Drug
Drinking / drug effects
Eating / drug effects
Feeding Behavior / drug effects*
Food Deprivation / physiology*
Motor Activity / drug effects
Peptide Hormones / pharmacology*
Rats, Sprague-Dawley
Sleep / drug effects*
Time Factors
Grant Support
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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