Document Detail


Ghrelin-induced feeding is dependent on nitric oxide.
MedLine Citation:
PMID:  12948844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ghrelin is a newly discovered gastric peptide, which has orexigenic effects. Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor and stimulates growth hormone and gastrointestinal motility. We have previously shown that nitric oxide (NO) plays an important role as a mediator of feeding induced by a variety of neuropeptides. This raises the question of whether ghrelin's effects are NO dependent. Here, we first determined that intracerebroventricular administration of 100 ng of ghrelin significantly increased food intake in satiated mice. We next examined the effects of N(omega)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, on ghrelin-induced increase in food intake. A subthreshold dose (12.5mg/kg; SC) of L-NAME significantly blocked the ghrelin-induced increase in food intake. Ghrelin administration increased the levels of nitric oxide synthase in the hypothalamus. This supports the hypothesis that nitric oxide is a central regulator of food consumption.
Authors:
F Spencer Gaskin; Susan A Farr; William A Banks; Vijaya B Kumar; John E Morley
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  24     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-09-01     Completed Date:  2004-06-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  913-8     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Geriatric Research Education and Clinical Center, VA Medical Center, Division of Geriatric Medicine, St. Louis University School of Medicine, 915 N. Grand Blvd., St. Louis, MO 63106, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Feeding Behavior / drug effects*
Ghrelin
Injections, Intraventricular
Male
Mice
NG-Nitroarginine Methyl Ester / pharmacology
Neuropeptide Y / metabolism
Nitric Oxide / metabolism*
Nitric Oxide Synthase / antagonists & inhibitors,  metabolism
Peptide Hormones / administration & dosage,  pharmacology*
Rats
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Neuropeptide Y; 0/Peptide Hormones; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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