| Ghrelin-induced feeding is dependent on nitric oxide. | |
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MedLine Citation:
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PMID: 12948844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ghrelin is a newly discovered gastric peptide, which has orexigenic effects. Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor and stimulates growth hormone and gastrointestinal motility. We have previously shown that nitric oxide (NO) plays an important role as a mediator of feeding induced by a variety of neuropeptides. This raises the question of whether ghrelin's effects are NO dependent. Here, we first determined that intracerebroventricular administration of 100 ng of ghrelin significantly increased food intake in satiated mice. We next examined the effects of N(omega)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, on ghrelin-induced increase in food intake. A subthreshold dose (12.5mg/kg; SC) of L-NAME significantly blocked the ghrelin-induced increase in food intake. Ghrelin administration increased the levels of nitric oxide synthase in the hypothalamus. This supports the hypothesis that nitric oxide is a central regulator of food consumption. |
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Authors:
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F Spencer Gaskin; Susan A Farr; William A Banks; Vijaya B Kumar; John E Morley |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Peptides Volume: 24 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-09-01 Completed Date: 2004-06-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 913-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Geriatric Research Education and Clinical Center, VA Medical Center, Division of Geriatric Medicine, St. Louis University School of Medicine, 915 N. Grand Blvd., St. Louis, MO 63106, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Drug Feeding Behavior / drug effects* Ghrelin Injections, Intraventricular Male Mice NG-Nitroarginine Methyl Ester / pharmacology Neuropeptide Y / metabolism Nitric Oxide / metabolism* Nitric Oxide Synthase / antagonists & inhibitors, metabolism Peptide Hormones / administration & dosage, pharmacology* Rats |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Neuropeptide Y; 0/Peptide Hormones; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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