| Ghrelin-induced adiposity is independent of orexigenic effects. | |
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MedLine Citation:
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PMID: 21543764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ghrelin is a hormone produced predominantly by the stomach that targets a number of specific areas in the central nervous system to promote a positive energy balance by increasing food intake and energy storage. In that respect, similarities exist with the effects of consuming a high-fat diet (HFD), which also increases caloric intake and the amount of stored calories. We determined whether the effects of ghrelin on feeding and adiposity are influenced by the exposure to an HFD. Chronic intracerebroventricular ghrelin (2.5 nmol/d) increased feeding in lean rats fed a low-fat control diet (CD) [192 ± 5 g (ghrelin+CD) vs. 152 ± 5 g (control i.c.v. saline+CD), P<0.001], but the combination of ghrelin plus HFD did not result in significantly greater hyperphagia [150 ± 7 g (ghrelin+HFD) vs. 136 ± 4 g (saline+HFD)]. Despite failing to increase food intake in rats fed the HFD, ghrelin nonetheless increased adiposity [fat mass increase of 14 ± 2 g (ghrelin+HFD) vs. 1 ± 1 g (saline+HFD), P<0.001] up-regulating the gene expression of lipogenic enzymes in white adipose tissue. Our findings demonstrate that factors associated with high-fat feeding functionally interact with pathways regulating the effect of ghrelin on food intake. We conclude that ghrelin's central effects on nutrient intake and nutrient partitioning can be separated and suggest an opportunity to identify respective independent neuronal pathways. |
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Authors:
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Diego Perez-Tilve; Kristy Heppner; Henriette Kirchner; Sarah H Lockie; Stephen C Woods; David L Smiley; Matthias Tschöp; Paul Pfluger |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-05-04 |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 25 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-02 Completed Date: 2011-10-14 Revised Date: 2012-09-25 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
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Languages: eng Pagination: 2814-22 Citation Subset: IM |
Affiliation:
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Metabolic Diseases Institute, Department of Internal Medicine, University of Cincinnati. 2180 E. Galbraith Rd., Cincinnati, OH 45237, USA. pereztdo@ucmail.uc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue, White
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drug effects,
physiology Adiposity / drug effects*, physiology Animals Dietary Fats / administration & dosage Eating / drug effects, physiology Ghrelin / administration & dosage, pharmacology*, physiology Hyperphagia / etiology, physiopathology Hypothalamus, Middle / drug effects, physiology Infusions, Intraventricular Lipogenesis / drug effects, genetics, physiology Male Melanocortins / antagonists & inhibitors, physiology Neuropeptides / physiology Rats Rats, Long-Evans Rats, Wistar Receptors, Neuropeptide / physiology Signal Transduction / drug effects, physiology Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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DK077975/DK/NIDDK NIH HHS; R01 DK017844-35/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Ghrelin; 0/Melanocortins; 0/Neuropeptides; 0/Receptors, Neuropeptide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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