| Ghrelin--an indicator for fat oxidation in obese children and adolescents during a weight reduction program. | |
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MedLine Citation:
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PMID: 17663297 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate the effect of short-term energy restriction combined with physical activity on changes in substrate oxidation and changes in plasma concentrations of ghrelin. We designed a longitudinal intervention study of 4.2 MJ (= 1,000 kcal) daily with exercise. Eighteen obese children and adolescents (age: 13.1 +/- 1.6 years, 13 girls, 5 boys, 17 White, 1 Black) participated. We measured body mass index (BMI), plasma ghrelin, resting energy expenditure (REE), VCO2, VO2 and respiratory quotient (RQ) at baseline and after 10 days. There was a significant decrease of BMI during the 10 day program (28.6 +/- 4.3 vs 27.5 +/- 4.2; p < 0.001). Ghrelin and RQ showed a tendency to increase, but the difference did not reach significance (ghrelin: 83.4 +/- 37.1 vs 99.5 +/- 41.2, p = 0067; RQ: 0.83 +/- 0.06 vs 0.85 +/- 0.08, p = 0.433). The changes in RQ were significantly and independently correlated with the changes in plasma ghrelin (p = 0.029). The increase in RQ suggests a shift from fat oxidation towards carbohydrate oxidation. Ghrelin reflects the same sensitivity as RQ to changes in energy balance. Therefore, ghrelin seems to be a sensitive indicator for changes in substrate oxidation. |
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Authors:
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Hildegard Nitsche; Marianne Nitsche; Karl Sudi; Matthias Tschop; Heinz Zotter; Gudrun Weinhand; Elke Froehlich-Reiterer; Siegfried Gallistl; Martina Pirker; Martin Borkenstein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric endocrinology & metabolism : JPEM Volume: 20 ISSN: 0334-018X ISO Abbreviation: J. Pediatr. Endocrinol. Metab. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-31 Completed Date: 2007-08-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9508900 Medline TA: J Pediatr Endocrinol Metab Country: England |
Other Details:
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Languages: eng Pagination: 719-23 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Graz, Austria. hildegard.nitsche@meduni-graz.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Biological Markers / blood* Body Mass Index Child Dietary Fats / pharmacokinetics* Energy Metabolism / physiology Female Ghrelin Humans Longitudinal Studies Male Motor Activity Obesity / blood*, diet therapy*, epidemiology Oxygen Consumption / physiology Peptide Hormones / blood* Physical Fitness Regression Analysis Sensitivity and Specificity Weight Loss / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dietary Fats; 0/Ghrelin; 0/Peptide Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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