Document Detail

Ghrelin improves left ventricular dysfunction and cardiac cachexia in heart failure.
MedLine Citation:
PMID:  12681236     Owner:  NLM     Status:  MEDLINE    
Ghrelin is a novel growth-hormone-releasing peptide isolated from the stomach that has been identified as an endogenous ligand for the growth-hormone secretagogue receptor. This peptide results in a positive energy balance by stimulating food intake and inducing adiposity through growth-hormone-independent mechanisms. In addition, ghrelin has several cardiovascular effects, as indicated by the presence of its receptor in blood vessels and ventricles of the heart. Infusion of ghrelin decreases systemic vascular resistance and increases cardiac output in patients with heart failure. Furthermore, repeated administration of ghrelin improves cardiac structure and function, and attenuates the development of cardiac cachexia in rats with heart failure. These results suggest that ghrelin has therapeutic potential in the treatment of severe chronic heart failure.
Noritoshi Nagaya; Kenji Kangawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  3     ISSN:  1471-4892     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-08     Completed Date:  2003-08-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  146-51     Citation Subset:  IM    
Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka, 565-8565, Japan.
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MeSH Terms
Cachexia / blood,  drug therapy*
Heart Failure / blood,  drug therapy*
Peptide Hormones / blood,  secretion,  therapeutic use*
Ventricular Dysfunction, Left / blood,  drug therapy*
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones

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