Document Detail

Ghrelin- and growth hormone secretagogue receptor-immunoreactive cells in Xenopus pancreas.
MedLine Citation:
PMID:  21549158     Owner:  NLM     Status:  Publisher    
Ghrelin and its receptor, growth hormone secretagogue receptor (GHS-R), are produced by various cell types and affect feeding behavior, metabolic regulation, and energy balance. In the mammalian pancreas, the types of endocrine cells immunoreactive for ghrelin vary. Further, no study has clarified the type of endocrine cells producing ghrelin and GHS-R in the non-mammalian pancreas. We immunohistochemically investigated ghrelin-like and GHS-R-like immunoreactivities in the Xenopus pancreas. Ghrelin-immunoreactive cells were observed both in islets and extrainsular regions, and they corresponded to insulin-containing cells. GHS-R-immunoreactive cells were observed in the islets, and these immunoreactive cells corresponded to insulin- and somatostatin-containing cells. These observations suggest that ghrelin is co-secreted with insulin and that ghrelin may act in an autocrine fashion for insulin-containing cells and in a paracrine fashion for somatostatin-containing cells in this species.
Hirohumi Suzuki; Toshiharu Yamamoto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-3
Journal Detail:
Title:  Regulatory peptides     Volume:  -     ISSN:  1873-1686     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Department of Biology, Fukuoka University of Education, Akamabunkyo-machi 1-1, Munakata, Fukuoka 811-4192, Japan.
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