Document Detail

Ghrelin augments afferent response to distension in rat isolated jejunum.
MedLine Citation:
PMID:  17109695     Owner:  NLM     Status:  MEDLINE    
Ghrelin has been shown to decrease firing of gastric vagal afferents at doses comparable with circulating levels in the fasted state. This raises the possibility that ghrelin may have a hormonal action on other vagal afferent populations. The aim of this study was to determine the effects of ghrelin on jejunal afferent activity; including responses to distension, 2-methyl-5-hydroxytryptamine (2-methyl-5-HT) and cholecystokinin (CCK) in both naïve and vagotomized rats. Ghrelin significantly augmented the afferent response to distension. No effect was observed on baseline afferent discharge, or the response to 2-methyl-5-HT and CCK. The effect of ghrelin was more pronounced at lower ramp distending pressures (0-30 mmHg). Similarly, ghrelin augmented the jejunal afferent responses to phasic distension at 10-30 mmHg, but had no effect at higher pressures. Chronic subdiaphragmatic vagotomy and administration of the growth hormone secretagogue receptor (GHS-R) antagonist [D-Lys3]-GHRP-6 prevented the augmentation of the afferent responses to distension indicating ghrelin is acting through the GHS-R on vagal afferent fibres. Ghrelin augments the mechanosensation of jejunal vagal afferents and hence may lead to increased perception of hunger contractions.
C D R Murray; C E Booth; D C E Bulmer; M A Kamm; A V Emmanuel; W J Winchester
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  18     ISSN:  1350-1925     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-19     Completed Date:  2007-01-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  1112-20     Citation Subset:  IM    
St Mark's Hospital, Harrow, UK.
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MeSH Terms
Balloon Dilatation
Cholagogues and Choleretics / pharmacology
Cholecystokinin / pharmacology
Hunger / physiology
Jejunum / innervation*,  physiology*
Mechanoreceptors / drug effects,  physiology
Oligopeptides / pharmacology
Peptide Hormones / pharmacology*,  physiology*
Rats, Sprague-Dawley
Serotonin / analogs & derivatives,  pharmacology
Sodium Chloride / pharmacology
Visceral Afferents / drug effects*,  physiology*
Reg. No./Substance:
0/Cholagogues and Choleretics; 0/Ghrelin; 0/Oligopeptides; 0/Peptide Hormones; 50-67-9/Serotonin; 7647-14-5/Sodium Chloride; 78263-90-8/2-methyl-5-HT; 87616-84-0/growth hormone releasing hexapeptide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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