Document Detail

Ghrelin and acyl ghrelin in preterm infants and maternal blood: relationship with endocrine and anthropometric measures.
MedLine Citation:
PMID:  18166814     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the present study was to examine the association of acylated and total ghrelin levels at birth in preterm infants with anthropometric features and with related hormones in infants and their mothers. DESIGN: Prospective, descriptive study. METHODS: In total 23 pregnant women and their 26 preterm infants were involved in the study (3 twin pregnancies; gestational age, 25-35 weeks). Maternal and umbilical vein blood samples were taken after the delivery. Serum acylated and total ghrelin, leptin, cortisol, insulin, GH, and glucose were determined. RESULTS: The mean level of acylated ghrelin concentration was higher in the maternal than in the cord blood (P<0.01) and there was a significant correlation between the fetal and maternal acylated ghrelin levels (P<0.01). The total ghrelin concentration was higher in neonates than in mothers (P<0.01), but there was no correlation between them. The multivariate regression analysis for fetal acylated and maternal total ghrelin as dependent variables shows that the fetal acylated ghrelin has two independent predictors, the maternal acylated ghrelin (P<0.01) and the fetal cortisol (P<0.05), whereas the maternal total ghrelin has only one independent predictor, the maternal glucose (P<0.05). CONCLUSIONS: These data provide the first evidence that umbilical cord acylated ghrelin concentrations are lower than in maternal blood and support the hypothesis that the acylation process in the fetus is partly affected by cortisol and the placenta may play a role in this process.
Eva Lányi; Akos Várnagy; Kálmán A Kovács; Tamás Csermely; Mária Szász; István Szabó
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  158     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-01     Completed Date:  2008-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
Department of Laboratory Medicine, Medical School, University of Pécs, 7624 Pécs József Au. 7. Pécs, Hungary.
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MeSH Terms
Birth Weight
Blood Glucose / metabolism
Fetal Blood / metabolism*
Ghrelin / blood*
Human Growth Hormone / blood
Hydrocortisone / blood
Infant, Newborn
Infant, Premature
Insulin / blood
Leptin / blood
Multivariate Analysis
Organ Size
Placenta / anatomy & histology
Prospective Studies
Regression Analysis
Reg. No./Substance:
0/Blood Glucose; 0/Ghrelin; 0/Leptin; 11061-68-0/Insulin; 12629-01-5/Human Growth Hormone; 50-23-7/Hydrocortisone

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