| Ghrelin plasma levels in patients with idiopathic short stature. | |
| | |
MedLine Citation:
|
PMID: 20861603 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background: Novel molecular insights have suggested that ghrelin may be involved in the pathogenesis of some forms of short stature. Recently, growth hormone secretagogue receptor (GHSR) mutations that segregate with short stature have been reported. Aim: To study plasma ghrelin levels in prepubertal patients with idiopathic short stature (ISS). Methods: Fasting total plasma ghrelin levels (radioimmunoassay) in 41 prepubertal patients with ISS (18 females, age 7.9 ± 0.5 years) compared with 42 age- and sex-matched controls (27 females, age 8.0 ± 0.3 years) with normal height. In a subset of 28 patients, the ghrelin receptor was sequenced. Results: ISS patients exhibited a higher level of ghrelin (1,458 ± 137 vs. 935 ± 55 pg/ml, p < 0.01) and similar IGF-I levels (-0.66 ± 1.29 vs. -0.32 ± 0.78 SDS) compared to controls. Ten patients with ISS had ghrelin levels greater than +2 SDS compared to controls. These patients did not differ in height, BMI or IGF-I SDS compared to ISS patients with ghrelin levels within the normal range. Molecular analysis of GHSR did not show any mutations, but showed some polymorphisms. Conclusion: These results suggest that in ISS patients, short stature does not appear to be frequently caused by abnormalities in ghrelin signaling. |
| | |
Authors:
|
Germán Iñiguez; Rossana Román; Ronald Youlton; Fernando Cassorla; Verónica Mericq |
Related Documents
:
|
12820323 - Cyfra 21-1 in diagnosis of distant metastases of head and neck carcinoma. 15986733 - The localization of central pattern generators for swallowing in humans--a clinical-ana... 19712853 - Collagenous colitis: description of a single centre series of 83 patients. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-23 |
Journal Detail:
|
Title: Hormone research in pædiatrics Volume: 75 ISSN: 1663-2826 ISO Abbreviation: Horm Res Paediatr Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-02-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101525157 Medline TA: Horm Res Paediatr Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 94-100 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 S. Karger AG, Basel. |
Affiliation:
|
Institute of Maternal and Child Research, University of Chile, Santiago, Chile. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The new generation of liquid intravenous immunoglobulin formulations in patient care: a comparison o...
Next Document: Toxic epidermal necrolysis with prominent facial pustules: a case with reactivation of human herpesv...