Document Detail

Ghrelin and Obestatin in Infants, Lactating Mothers and Breast Milk.
MedLine Citation:
PMID:  23257416     Owner:  NLM     Status:  Publisher    
Aim: To investigate the role of ghrelin and obestatin in infancy. Methods: We measured ghrelin and obestatin concentrations in blood samples of infants, lactating mothers, and in breast milk. Results: The median (interquartile range) serum ghrelin concentrations were 922.11 (868.44) pg/ml in infants, 667.88 (942.78) pg/ml in lactating mothers, and 526.4 (439.86) pg/ml in breast milk. The serum obestatin levels were 844.87 (805.14) pg/ml in infants, 759.105 (855.55) pg/ml in lactating mothers, and 846.6 (472.07) pg/ml in breast milk. A positive correlation was found for serum ghrelin concentrations in breastfed infants and lactating mothers (p < 0.001, r = 0.789), serum ghrelin concentrations in breastfed infants and in breast milk (p < 0.001, r = 0.581), serum ghrelin concentrations in lactating mothers and in breast milk (p = 0.021, r = 0.450), and serum obestatin concentrations in breastfed infants and in lactating mothers (p = 0.047, r = 0.609). Conclusion: We report for the first time the serum obestatin concentrations in infants and confirm the presence of correlations between ghrelin and obestatin in lactating mothers and breast milk. The correlations found early in infants' life, when hormones begin to exert their effects on feeding behavior, suggest that they may be involved in these processes.
F Savino; S Benetti; M M Lupica; E Petrucci; E Palumeri; L Cordero di Montezemolo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-18
Journal Detail:
Title:  Hormone research in paediatrics     Volume:  -     ISSN:  1663-2826     ISO Abbreviation:  Horm Res Paediatr     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101525157     Medline TA:  Horm Res Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  297-303     Citation Subset:  -    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
Department of Paediatrics, University of Turin, Regina Margherita Children's Hospital, Turin, Italy.
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