| Ghrelin and Obestatin in Infants, Lactating Mothers and Breast Milk. | |
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MedLine Citation:
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PMID: 23257416 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To investigate the role of ghrelin and obestatin in infancy. Methods: We measured ghrelin and obestatin concentrations in blood samples of infants, lactating mothers, and in breast milk. Results: The median (interquartile range) serum ghrelin concentrations were 922.11 (868.44) pg/ml in infants, 667.88 (942.78) pg/ml in lactating mothers, and 526.4 (439.86) pg/ml in breast milk. The serum obestatin levels were 844.87 (805.14) pg/ml in infants, 759.105 (855.55) pg/ml in lactating mothers, and 846.6 (472.07) pg/ml in breast milk. A positive correlation was found for serum ghrelin concentrations in breastfed infants and lactating mothers (p < 0.001, r = 0.789), serum ghrelin concentrations in breastfed infants and in breast milk (p < 0.001, r = 0.581), serum ghrelin concentrations in lactating mothers and in breast milk (p = 0.021, r = 0.450), and serum obestatin concentrations in breastfed infants and in lactating mothers (p = 0.047, r = 0.609). Conclusion: We report for the first time the serum obestatin concentrations in infants and confirm the presence of correlations between ghrelin and obestatin in lactating mothers and breast milk. The correlations found early in infants' life, when hormones begin to exert their effects on feeding behavior, suggest that they may be involved in these processes. |
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Authors:
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F Savino; S Benetti; M M Lupica; E Petrucci; E Palumeri; L Cordero di Montezemolo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-18 |
Journal Detail:
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Title: Hormone research in paediatrics Volume: - ISSN: 1663-2826 ISO Abbreviation: Horm Res Paediatr Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101525157 Medline TA: Horm Res Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: 297-303 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Department of Paediatrics, University of Turin, Regina Margherita Children's Hospital, Turin, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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