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GH DEFICIENCY IN THE TRANSITION PERIOD: BODY COMPOSITION AND GONAD FUNCTION.
MedLine Citation:
PMID:  21697646     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recombinant growth hormone therapy is normally administered to GH-deficient children in order to achieve a satisfactory height - the main target during childhood and adolescence. However, the role of GH does not end once final height has been reached, but continues during the so-called transition period. In this phase of life the body undergoes several changes, both physical and psychological, that culminate in adulthood. During this period, GH has a part in numerous metabolic functions. These include the lipid profile, where it increases HDL and reduces LDL, with the global effect of cardiovascular protection. It also has important effects on body composition (improved muscle strength and lean body mass, and reduced body fat), the achievement of proper peak bone density and gonad maturation. Retesting during the transition period, involving measurement of IGF-1 plus a provocative test (insulin tolerance test or GHRH + Arginine Test), is thus necessary to establish any persistent GH-deficiency requiring additional replacement therapy. The close cooperation of the medical professionals involved in the patient's transition from a paediatric to an adult endocrinologist is essential. The aim of this review is to point out the main aspects of GH treatment on body composition, metabolic and gonad functions in the transition period.
Authors:
Giancarlo Balercia; Lara Giovannini; Francesca Paggi; Matteo Spaziani; Natascia Tahani; Marco Boscaro; Andrea Lenzi; Antonio Radicioni
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-21
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  -     ISSN:  1720-8386     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Medical Andrology, Endocrinology, Dept of Internal medicine and Applied Biotechnologies, Politechnic University of Marche, Umberto I Hospital, Ancona.
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