Document Detail

MedLine Citation:
PMID:  21697646     Owner:  NLM     Status:  Publisher    
Recombinant growth hormone therapy is normally administered to GH-deficient children in order to achieve a satisfactory height - the main target during childhood and adolescence. However, the role of GH does not end once final height has been reached, but continues during the so-called transition period. In this phase of life the body undergoes several changes, both physical and psychological, that culminate in adulthood. During this period, GH has a part in numerous metabolic functions. These include the lipid profile, where it increases HDL and reduces LDL, with the global effect of cardiovascular protection. It also has important effects on body composition (improved muscle strength and lean body mass, and reduced body fat), the achievement of proper peak bone density and gonad maturation. Retesting during the transition period, involving measurement of IGF-1 plus a provocative test (insulin tolerance test or GHRH + Arginine Test), is thus necessary to establish any persistent GH-deficiency requiring additional replacement therapy. The close cooperation of the medical professionals involved in the patient's transition from a paediatric to an adult endocrinologist is essential. The aim of this review is to point out the main aspects of GH treatment on body composition, metabolic and gonad functions in the transition period.
Giancarlo Balercia; Lara Giovannini; Francesca Paggi; Matteo Spaziani; Natascia Tahani; Marco Boscaro; Andrea Lenzi; Antonio Radicioni
Related Documents :
16967996 - Photoconductive characteristics of single-crystal cds nanoribbons.
11665646 - Chronic toxicity and oncogenicity of n-methylpyrrolidone (nmp) in rats and mice by diet...
14563406 - Lack of modifying effects of atrazine and/or tamoxifen on thyroid carcinogenesis in rat...
11817686 - Effects of ingestion of cadmium-polluted rice or low-dose cadmium-supplemented diet on ...
6643296 - Plasma clearance of l- and d-lactate in steers fed alfalfa hay or high concentrate diets.
1512626 - Dietary beta-carotene reduces serum lipid concentrations in spontaneously hypertensive ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-21
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  -     ISSN:  1720-8386     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Medical Andrology, Endocrinology, Dept of Internal medicine and Applied Biotechnologies, Politechnic University of Marche, Umberto I Hospital, Ancona.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Glucosamine induces cell death via proteasome inhibition in human ALVA41 prostate cancer cell.
Next Document:  Role of the energy sensor AMP-activated protein kinase in the regulation of immature GnRH neuron mig...