Document Detail


Getting under the skin: the immunogenetics of psoriasis.
MedLine Citation:
PMID:  16138103     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Psoriasis is a chronic inflammatory disorder of the skin that is mediated by T cells, dendritic cells and inflammatory cytokines. We now understand many of the cellular alterations that underlie this disease, and genomic approaches have recently been used to assess the alterations of gene expression in psoriatic skin lesions. Genetic susceptibility factors that contribute to predisposition to psoriasis are now also being identified. It is hoped that we will soon be able to correlate the cellular pathogenesis that occurs in psoriasis with these genetic factors. In this Review article, we describe what is known about genes that confer increased susceptibility to psoriasis, and we integrate this with what is known about the molecular and cellular mechanisms that occur in other inflammatory and autoimmune disorders.
Authors:
Anne M Bowcock; James G Krueger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  5     ISSN:  1474-1733     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-02     Completed Date:  2005-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  699-711     Citation Subset:  IM    
Affiliation:
Department of Genetics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA. Bowcock@genetics.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Humans
Immunity, Cellular / genetics
Psoriasis / genetics*,  immunology*,  pathology
Comments/Corrections
Erratum In:
Nat Rev Immunol. 2005 Oct;5(10):826

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