Document Detail


Gestational trophoblastic neoplasia: clinical trends in 8 years at Hospital Universitario de Caracas.
MedLine Citation:
PMID:  17165435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To analyze the clinical trends of gestational trophoblastic neoplasia (GTN) at the Department of Obstetrics and Gynecology, Hospital Universitario de Caracas (HUC). STUDY DESIGN: A medical record review was performed of epidemiologic, clinical and diagnostic features of 25 cases of GTN at HUC from 1997 to 2004. RESULTS: During the study period, 35,300 deliveries occurred, and 25 patients were diagnosed with GTN; the prevalence was 0.70:1,000 deliveries. The mean age was 29.2 years. Fifty-six percent were posthydatidiform mole (HM), 36% postchoriocarcinoma (CC), 4% postinvasive mole and 4% postabortion with abundant intermediate trophoblast. Vaginal bleeding was the main symptom in patients with CC. Two cases resembled ectopic pregnancy, and another resembled a vaginal endometrioma. Fifty-two percent of cases were at stage Ib; 76% received single-agent chemotherapy. Hysterectomy was performed in 6 cases. Twenty-one patients achieved remission, 2 showed regression and 2 died. CONCLUSION: GTN had a high prevalence because HUC is a reference center. The most common presentation was post-HM GTN. Vaginal bleeding is frequent in CC and can mimic other gynecologic diseases. Chemotherapy is helpful, and hysterectomy can be performed in selected cases at early stages or with severe vaginal bleed-with a good ing. GTN has a good prognosis, and early diagnosis is possible.
Authors:
Rafael Cortés-Charry; Lina M Figueira; Victoria García-Barriola; Miriam de Gómez; Zhari Vivas; Aleydah Salazar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  51     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-12-14     Completed Date:  2007-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  888-91     Citation Subset:  IM    
Affiliation:
Obstetrics and Gynecology Department, Hospital Universitario de Caracas and Oncology Institute, Caracas, Venezuela. rafacort083@cantv.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Choriocarcinoma / complications,  epidemiology*
Chorionic Gonadotropin / blood
Female
Gestational Trophoblastic Neoplasms / epidemiology*,  therapy
Hemorrhage / etiology
Humans
Hydatidiform Mole / complications,  epidemiology*
Middle Aged
Pregnancy
Prevalence
Prognosis
Retrospective Studies
Uterine Neoplasms / complications,  epidemiology
Vaginal Diseases / etiology
Venezuela / epidemiology
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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