Document Detail

Gestational thrombocytopenia: a prospective study.
MedLine Citation:
PMID:  9234586     Owner:  NLM     Status:  MEDLINE    
Gestational thrombocytopenia (GT) is commonly observed in pregnancies with otherwise limited obstetric and hematologic complications. However, few data are available on the natural history of the disease, and on the recurrence of thrombocytopenia in subsequent pregnancies. From June 1987 to December 1993, 37 consecutive patients with GT were enrolled in a prospective study, with a total of 41 pregnancies observed. Vaginal delivery was carried out in 33/41 (80%); two patients were transfused fused with packed red cells for obstetric hemorrhage (post-partum uterine atony). Neonatal bleeding did not occur. In all newborns platelet count was performed within 24 hours after delivery: 2 newborns had mild (80 and 75 x 10(9)/L) and 1 severe thrombocytopenia (12 x 10(9)/L) at birth; all of them recovered to a normal platelet count within 10 days without treatment. Twenty-eight out of 3% patients were followed for 12 months after delivery; in 23 a normalization of platelet count occurred within 1-5 months from delivery; in 5 mild thrombocytopenia (100-120 x 10(9)/L) persisted during follow-up. Four patients had a second pregnancy and recurrence of thrombocytopenia was observed in all of them. GT is rarely associated with bleeding episodes during pregnancy and partum, and recovers spontaneously within few months after delivery but thrombocytopenia can recur in subsequent pregnancies. Severe thrombocytopenia is not observed in newborns so that a conservative management is warranted.
M Ruggeri; C Schiavotto; G Castaman; A Tosetto; F Rodeghiero
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Haematologica     Volume:  82     ISSN:  0390-6078     ISO Abbreviation:  Haematologica     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-09-19     Completed Date:  1997-09-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  341-2     Citation Subset:  IM    
Department of Hematology, San Bortolo Hospital, Vicenza, Italy.
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MeSH Terms
Infant, Newborn
Italy / epidemiology
Platelet Count
Postpartum Hemorrhage / epidemiology,  etiology
Pregnancy Complications, Hematologic / epidemiology*
Pregnancy Outcome
Prospective Studies
Thrombocytopenia / congenital,  epidemiology*

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