| Gestational surrogacy: a feasible option for patients with Rokitansky syndrome. | |
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MedLine Citation:
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PMID: 11056126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rokitansky syndrome is a developmental defect characterized by agenesis of the uterus and vagina but normal gonads and secondary sexual characters. It is not commonly transmitted as a dominant genetic trait. Surrogacy, which is legally and ethically accepted in the UK and other countries, has made it possible for the patients with this syndrome to have their own genetic children. Six patients with Rokitansky syndrome underwent 11 ovarian stimulation cycles that resulted in 11 fresh and three frozen embryo transfer procedures into six prospective surrogate mothers. Both commissioning and surrogate couples were properly screened and counselled and their treatment was approved by the clinic internal review committee (ethics committee). The treatment cycles resulted in six clinical pregnancies (42.9% pregnancy rate per embryo transfer and 54.5% per oocyte retrieval) and three live births (21. 4% per embryo transfer, 27.3% per retrieval and 50% per patient). Gestational surrogacy is a viable treatment for patients with Rokitansky syndrome. Such patients should be well informed and supported to be able to have a family using their own genetic gametes. |
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Authors:
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S Beski; A Gorgy; G Venkat; I L Craft; K Edmonds |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 15 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-27 Completed Date: 2000-12-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2326-8 Citation Subset: IM |
Affiliation:
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Chelsea and Westminster Hospital, London SW10 9NH, London Gynaecology and Fertility Centre, 112A Harley Street, London W1N 1AF and Queen Charlotte and Chelsea Hospital, London W6 0XG, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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physiopathology Adult Birth Rate Embryo Transfer Feasibility Studies Female Fertilization in Vitro Humans Male Pregnancy Pregnancy Rate Retrospective Studies Surrogate Mothers* Syndrome Uterus / abnormalities* Vagina / abnormalities* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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