Document Detail

Gestational progesterone suppresses embryotoxic action of the complement system to chick embryo.
MedLine Citation:
PMID:  11335877     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: In this paper the relation between progesterone levels and embryotoxic effect of serum complement was studied. DESIGN: The aim of this study was to validate hypothesis that progesterone is strong inhibitor of complement embryotoxic action. SETTING: We used chick embryo like an experimental model for evidence of our hypothesis. We treated chick embryos by sera acquired from healthy pregnant woman with physiologically elevated levels of progesterone and normal complement activity. We investigated embryotoxicity of these sera. RESULT: We noticed a significant decrease of sera embryotoxicity inversely related to serum levels of progesterone. The main finding: The embryotoxicity of sera is reversally dependent on progesterone level. CONCLUSIONS: These findings bring a new knowledge to the role of progesterone and complement system mainly in initial stages of pregnancy and in some cases of spontaneous abortions.
M Zeman; P Nováková
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  22     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-03     Completed Date:  2001-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  IM    
Charles University, 3rd Faculty of Medicine, Center of Biomedical Sciences, Prague, Czech Republic.
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MeSH Terms
Chick Embryo
Complement System Proteins / metabolism*,  toxicity
Embryo, Mammalian / abnormalities,  metabolism*
Factor Analysis, Statistical
Gestational Age
Maternal-Fetal Exchange
Models, Biological*
Pregnancy / blood*,  immunology
Progesterone / blood*
Reg. No./Substance:
57-83-0/Progesterone; 9007-36-7/Complement System Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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