Document Detail


Gestational naltrexone ameliorates fetal ethanol exposures enhancing effect on the postnatal behavioral and neural response to ethanol.
MedLine Citation:
PMID:  23045720     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association between gestational exposure to ethanol and adolescent ethanol abuse is well established. Recent animal studies support the role of fetal ethanol experience-induced chemosensory plasticity as contributing to this observation. Previously, we established that fetal ethanol exposure, delivered through a dam's diet throughout gestation, tuned the neural response of the peripheral olfactory system of early postnatal rats to the odor of ethanol. This occurred in conjunction with a loss of responsiveness to other odorants. The instinctive behavioral response to the odor of ethanol was also enhanced. Importantly, there was a significant contributory link between the altered response to the odor of ethanol and increased ethanol avidity when assessed in the same animals. Here, we tested whether the neural and behavioral olfactory plasticity, and their relationship to enhanced ethanol intake, is a result of the mere exposure to ethanol or whether it requires the animal to associate ethanol's reinforcing properties with its odor attributes. In this later respect, the opioid system is important in the mediation (or modulation) of the reinforcing aspects of ethanol. To block endogenous opiates during prenatal life, pregnant rats received daily intraperitoneal administration of the opiate antagonist naltrexone from gestational day 6-21 jointly with ethanol delivered via diet. Relative to control progeny, we found that gestational exposure to naltrexone ameliorated the enhanced postnatal behavioral response to the odor of ethanol and postnatal drug avidity. Our findings support the proposition that in utero ethanol-induced olfactory plasticity (and its relationship to postnatal intake) requires, at least in part, the associative pairing between ethanol's odor quality and its reinforcing aspects. We also found suggestive evidence that fetal naltrexone ameliorated the untoward effects of gestational ethanol exposure on the neural response to non-fetal-exposure odorants. Thus, gestational naltrexone may also have a neuroprotective and/or neuroproliferative impact on olfactory development.
Authors:
Steven L Youngentob; Paul F Kent; Lisa M Youngentob
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-08
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  237     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-01     Completed Date:  2013-02-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1197-208     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA. youngens@upstate.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Behavior, Animal
Ethanol / pharmacology*
Female
Maternal Exposure
Maternal-Fetal Exchange*
Naltrexone / pharmacology*
Neuroprotective Agents / pharmacology*
Odors
Pregnancy
Prenatal Exposure Delayed Effects / metabolism,  physiopathology*,  psychology*
Rats
Rats, Sprague-Dawley
Smell
Grant Support
ID/Acronym/Agency:
AA014871/AA/NIAAA NIH HHS; AA017823/AA/NIAAA NIH HHS; P50 AA017823/AA/NIAAA NIH HHS; R01 AA014871/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/Neuroprotective Agents; 16590-41-3/Naltrexone; 64-17-5/Ethanol
Comments/Corrections

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