| Gestational and lactational transfer of melamine following gavage administration of a single dose to rats. | |
| | |
MedLine Citation:
|
PMID: 21457748 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Melamine contamination in an infant formula manufactured by a firm in China was reported in September 2008. Maternal transfer of melamine during pregnancy and through breast-feeding are possible ways of introduction. This study aims to evaluate the maternal transfer of melamine into amniotic fluid and breast milk through oral intake by pregnant and lactating rats, respectively. The quantity of melamine in the dam's sera, amniotic fluid, breast milk as well as in fetal whole body extract was measured. Our results showed that, after administration of single dose of 21.4 mg/kg per body weight of melamine to pregnant rats (16-18 days of gestation) by gavage, about 80% of melamine was found in dam's serum in 0.5 hour. Melamine further reached the fetuses through placental transfer as it was found that peak melamine level of 7.15 ppm (∼30%) was detected in the fetuses after 2 hours and 4.36 ppm (∼20%) was shown in amniotic fluid after 3 hours of maternal intake. In the lactating rats, about 40% of maternal intake of melamine was transferred to breast milk and peaked at 3 hours. The results of this study confirmed the maternal transfer of melamine to fetuses in utero and infants through breast feeding. |
| | |
Authors:
|
Judy Yuet Wa Chan; Chau Ming Lau; Tai Lun Ting; Thomas Chung Wai Mak; Michael Ho Ming Chan; Christopher Wai Kei Lam; Chung Shun Ho; Ronald Chi Chiu Wang; Tai Fai Fok; Kwok Pui Fung |
Related Documents
:
|
1962518 - Serum concentrations of pregnancy-associated alpha-2-glycoprotein in diabetic pregnancy... 16263858 - Lithium placental passage and obstetrical outcome: implications for clinical management... 12099308 - Identification of fetal growth abnormalities in diabetes mellitus. 3065158 - Complications and fetal outcome in diabetic pregnancy. intensified conventional versus ... 8949808 - Inflammatory changes after extradural anaesthesia may affect the spread of local anaest... 683628 - Pregnancy specific beta1 glycoprotein in fetal and maternal compartments. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-29 |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: - ISSN: 1873-6351 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-4-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phytochemical profile, antioxidant, anti-inflammatory and hypoglycemic potential of hydroalcoholic e...
Next Document: Application of the TTC concept to unknown substances found in analysis of foods.