| Gestational exposure to bisphenol A and cross-fostering affect behaviors in juvenile mice. | |
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MedLine Citation:
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PMID: 20691692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bisphenol-A (BPA) is a component of polycarbonate resins, and, lately, concern has been raised about its potential negative effects on human health. BPA is an estrogen analog and, in addition, it can act as a DNA hypomethylator. We examined the effects of gestational exposure to BPA on several behaviors in C57BL/6J mice. Because BPA affects maternal care, which, may have long-lasting effects on offspring behavior, we tested mice raised by either biological or fostered dams. Both diet and dam affected behavior in juvenile mice in a social novelty task and the elevated plus maze (EPM). In a social novelty task, the amount of time spent interacting with an adult male was affected by sex and gestational diet, but only in juveniles raised by a foster dam. Control females spent less time sniffing a novel adult than did control males or females exposed to BPA during gestation. In the EPM, juveniles reared by foster dams and exposed to BPA during gestation spent less time in the distal half of the open arm as compared with juveniles gestated on a control diet. Adult offspring raised by their biological dams showed the same response pattern; gestational BPA increased anxiety as compared with control diet. Our results show that prenatal BPA exposure affects social behavior and anxiety in the EPM. Moreover, some facet(s) of the infant-maternal interaction may modify these effects. |
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Authors:
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Kimberly H Cox; Jessica D Gatewood; Chelsea Howeth; Emilie F Rissman |
Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-05 |
Journal Detail:
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Title: Hormones and behavior Volume: 58 ISSN: 1095-6867 ISO Abbreviation: Horm Behav Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2011-03-08 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 0217764 Medline TA: Horm Behav Country: United States |
Other Details:
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Languages: eng Pagination: 754-61 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Air Pollutants
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toxicity Animal Husbandry Animals Animals, Newborn Anxiety / chemically induced Behavior, Animal / drug effects, physiology* Exploratory Behavior / drug effects, physiology Female Male Maternal Deprivation* Maternal Exposure / adverse effects* Maze Learning / drug effects, physiology Mice Mice, Inbred C57BL Phenols / toxicity* Pregnancy Prenatal Exposure Delayed Effects / physiopathology*, psychology |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH086711/MH/NIMH NIH HHS; R01 MH086711-02/MH/NIMH NIH HHS; T32 HD007323/HD/NICHD NIH HHS; T32 HD007323-24/HD/NICHD NIH HHS; U54-HD28934/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Phenols; 80-05-7/bisphenol A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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