Document Detail

Gestational diabetes mellitus--implications of different treatment protocols.
MedLine Citation:
PMID:  15270402     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the impact of different management approaches to gestational diabetes mellitus (GDM) on perinatal outcome. PATIENTS AND METHODS: The study group consisted of 2,060 patients with GDM treated in our center from January 1980 through December 1999. Four time periods were defined on the basis of changes in treatment protocols. Perinatal complications were compared between the periods and with normal pregnancy controls. RESULTS: The last two periods (1993-1999) were characterized by lower mean glucose level, lower mean gestational age at delivery, and a decline in macrosomia, shoulder dystocia and perinatal mortality rates, but also by high rates of labor induction and Cesarean delivery. A significant difference was found between the GDM and normal control groups in rates of labor induction (38.6% vs 10.8%, p < 0.001) and Cesarean delivery (34% vs 20%, p < 0.001) for the last period. CONCLUSIONS: Perinatal complications are preventable with good glycemic control and early induction of labor, but at a cost of a higher Cesarean section rate.
Yoav Peled; Tamar Perri; Rony Chen; Joseph Pardo; Jacob Bar; Moshe Hod
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  17     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-23     Completed Date:  2004-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  847-52     Citation Subset:  IM    
Perinatal Division and WHO Collaborating Center for Perinatal Care, Department of Obstetrics & Gynecology, Rabin Medical Center, Petah Tiqva, Israel.
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MeSH Terms
Blood Glucose / metabolism
Cesarean Section / statistics & numerical data
Delivery, Obstetric
Diabetes, Gestational / drug therapy*
Dose-Response Relationship, Drug
Drug Administration Schedule
Dystocia / epidemiology
Fetal Macrosomia / epidemiology
Gestational Age
Hypoglycemic Agents / administration & dosage*,  therapeutic use
Infant Mortality
Infant, Newborn
Insulin / administration & dosage*,  therapeutic use
Labor Presentation
Labor, Induced / statistics & numerical data
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Blood Glucose; 0/Hypoglycemic Agents; 11061-68-0/Insulin

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