Document Detail


Gestational diabetes, atopic dermatitis, and allergen sensitization in early childhood.
MedLine Citation:
PMID:  19733904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The relationship between the prenatal environment, maternal-fetal interaction, and allergic disease in the offspring remains understudied.
OBJECTIVE: We sought to determine whether gestational diabetes (GDM) modifies the risk of early childhood atopic manifestations, including atopic dermatitis and allergen sensitization.
METHODS: This study includes 680 children from the Boston Birth Cohort. Mother-child dyads were recruited at birth and followed prospectively to a mean age of 3.2 +/- 2.3 years, with study visits aligned with the pediatric primary care schedule. The primary outcomes were physician-diagnosed atopic dermatitis on standardized medical record abstraction and allergen sensitization based on ImmunoCAP to 7 common foods and 5 common aeroallergens (specific IgE, >or=0.10 kUA/L; Phadia, Uppsala, Sweden). GDM was determined by means of standardized medical record review. Logistic regression analysis, stratified by term/preterm status, evaluated the association of GDM with atopic dermatitis and allergen sensitization, respectively, controlling for maternal prepregnancy body mass index, fetal growth, and pertinent covariates.
RESULTS: Of the 680 children, 488 were term, and 192 were preterm (<37 weeks' gestation). Overall, 4.9% of the mothers had GDM. Among the 680 children, 34.4% had atopic dermatitis, and 51% had allergen sensitization. In term births GDM was significantly associated with atopic dermatitis (odds ratio [OR], 7.2; 95% CI, 1.5-34.5) and allergen sensitization (OR, 5.7; 95% CI, 1.2-28.0). Adjusting for fetal growth had little effect. The association with sensitization was driven primarily by food sensitization (OR, 8.3; 95% CI, 1.6-43.3). The above associations were not observed in preterm births.
CONCLUSIONS: In term births GDM increased the risk of atopic dermatitis and early childhood allergen sensitization independently of maternal prepregnancy body mass index and fetal growth.
Authors:
Rajesh Kumar; Fengxiu Ouyang; Rachel E Story; Jacqueline A Pongracic; Xiumei Hong; Guoying Wang; Colleen Pearson; Kathryn Ortiz; Howard Bauchner; Xiaobin Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-09-06
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  124     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2009-11-24     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1031-8.e1-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Child
Child, Preschool
Cohort Studies
Dermatitis, Atopic / epidemiology*,  immunology
Diabetes, Gestational / epidemiology*,  immunology
Female
Humans
Hypersensitivity / epidemiology*,  immunology
Infant
Infant, Newborn
Male
Maternal-Fetal Relations
Pregnancy
Prevalence
Grant Support
ID/Acronym/Agency:
K23 HL093023/HL/NHLBI NIH HHS; K23HL093023/HL/NHLBI NIH HHS; R01 HD041702/HD/NICHD NIH HHS; R01 HD041702/HD/NICHD NIH HHS; R21 ES011666/ES/NIEHS NIH HHS; R21 ES011666/ES/NIEHS NIH HHS; R21AI079872/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Allergens
Comments/Corrections

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