Document Detail

Gestational age correlates with skin reflectance in newborn infants of 24-42 weeks gestation.
MedLine Citation:
PMID:  8260548     Owner:  NLM     Status:  MEDLINE    
Accurate gestational age determination is limited in very low birthweight infants using neurological and physical assessments. As one of the markers of intrauterine development, skin maturation is assessed qualitatively by pediatricians. Based on this observation, we hypothesize that skin reflectance relates directly to gestational age. Light was delivered and collected from the skin through a topically placed optical patch. Reflected light was detected by the spectrophotometer and corrected by an adjacent laptop computer to yield the true total diffuse reflectance as a function of wavelength between 380-820 nm. The calculated reflectance at 837 nm (R837) where it is independent of melanin, was determined by extrapolation from the reflectance at 650 and 750 nm. Sixty-four neonates of different races with gestational ages of 24-42 weeks were studied at 2-151 h of age. R837 was related exponentially to gestational age (GA) by the equation R837 = Rmax(1-exp[-(GA-G0)/tau]), where Rmax is the maximal value of R837, G0 is an apparent delay time before dermal scattering increases rapidly, and tau is a time constant, r = 0.88, p < 0.001. In summary, the extrapolated skin reflectance offers a quantitative and objective assessment of gestational age which is independent of melanin and sex.
C J Lynn; I S Saidi; D G Oelberg; S L Jacques
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  64     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1993  
Date Detail:
Created Date:  1994-01-27     Completed Date:  1994-01-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  69-75     Citation Subset:  IM    
Department of Pediatrics, University of Texas Health Science Center at Houston.
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MeSH Terms
African Continental Ancestry Group
European Continental Ancestry Group
Gestational Age*
Hispanic Americans
Infant, Newborn*
Infant, Premature*
Skin Physiological Phenomena*
Grant Support

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