Document Detail

Gestational age and birth weight in relation to n-3 fatty acids among Inuit (Canada).
MedLine Citation:
PMID:  15588018     Owner:  NLM     Status:  MEDLINE    
Seafood consumption during pregnancy carries both benefits (high n-3 FA intake) and risks (exposure to environmental contaminants) for the developing fetus. We determined the impacts of marine n-3 FA and environmental contaminants on gestational age (GA) of Nunavik women and the anthropometric characteristics of their newborns. FA and contaminant (polychlorinated biphenyls and mercury) concentrations were measured in cord plasma of Nunavik newborns (n = 454) and compared with those of a group of newborns (n = 29) from southern Québec. Data were collected from hospital records and birth certificates. In Nunavik newborns, arachidonic acid (AA) was two times lower (P < 0.0001), whereas DHA concentration, the sigman-3 / sigman-6 ratio, and the percentage of n-3 highly unsaturated FA (HUFA) (of the total HUFA) were three times higher (P < 0.0001) compared with southern Québec newborns. After controlling for confounders, GA and birth weight were higher by 5.4 d [95% confidence interval (CI): 0.7-10.1] and 77 g (95% CI: -64 to 217) in the third tertile of percentage of n-3 HUFA (of the total HUFA) as compared with the first tertile. There was no evidence that contaminants had negative effects on GA or birth weight. In this seafood-eating population, an increase in the proportion of n-3 HUFA (of the total HUFA), measured in umbilical cord plasma phospholipids, was associated with a significantly longer GA.
Michel Lucas; Eric Dewailly; Gina Muckle; Pierre Ayotte; Suzanne Bruneau; Suzanne Gingras; Marc Rhainds; Bruce J Holub
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  39     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  617-26     Citation Subset:  IM    
Public Health Research Unit, Laval University Medical Research Centre, Centre Hospitalier Universitaire de Québec, Québec G1V 5B3, Canada.
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MeSH Terms
Birth Weight*
Environmental Pollutants / toxicity
Fatty Acids, Omega-3 / chemistry,  metabolism*
Fetal Blood / chemistry
Gestational Age*
Infant, Newborn
Pregnancy Outcome
Statistics as Topic
Reg. No./Substance:
0/Environmental Pollutants; 0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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