Document Detail


Gestational age and birth weight effects on plasma clearance of fentanyl in newborn infants.
MedLine Citation:
PMID:  10839874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To provide a rational basis for the dosage of fentanyl in newborn infants by determining clearance in the first days of life. STUDY DESIGN: A continuous infusion of fentanyl for 2 to 3 days (10. 5 microg/kg over a 1-hour period followed by 1.5 microg/kg/h) was administered to 38 newborn infants who had undergone ventilation (gestational ages 26 to 42 weeks and birth weights 835 to 3550 g). Fentanyl concentrations were measured in arterial blood samples collected at 2, 12, 24, 48, and 60 hours after the start of fentanyl infusion. Fentanyl levels were correlated with a pain score. RESULTS: The mean (+/-SD) steady-state fentanyl concentration of 2.5 (+/-1) ng/mL achieved between 24 and 48 hours of infusion correlated significantly with the concomitant pain score (r = -0.57, P <.01). The clearance, 11.5 (+/-4.0) mL/min/kg, correlated significantly with the gestational age (r = 0.46, P <.01) and birth weight (r = 0. 48, P <.01). CONCLUSIONS: Because plasma fentanyl clearance increases with maturity, gestational age should be taken into account when fentanyl is administered to newborn infants.
Authors:
E Saarenmaa; P J Neuvonen; V Fellman
Related Documents :
409094 - Total parenteral nutrition in infants. blood levels of glucose, lactate, pyruvate, free...
23526654 - Reproductive parameters of female macaca mulatta tcheliensis in the temperate forest of...
23265254 - Maternal interactive behaviour as a predictor of preschoolers' attachment representatio...
1255324 - Neonatal hyperuricemia.
18977994 - Hospital discharge of the high-risk neonate.
11383704 - Late-onset cystic periventricular leukomalacia in premature infants: a threat until term.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  136     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-18     Completed Date:  2000-07-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  767-70     Citation Subset:  AIM; IM    
Affiliation:
Hospital for Children and Adolescents and the Department of Clinical Pharmacology, University of Helsinki, Finland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid / blood*,  pharmacokinetics*
Birth Weight*
Female
Fentanyl / blood*,  pharmacokinetics*
Gestational Age*
Humans
Infant, Newborn
Male
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vascular retinal abnormalities in neonates of mothers who smoked during pregnancy.
Next Document:  A new blue light-emitting phototherapy device: a prospective randomized controlled study.