Document Detail

Gestational pemphigoid: placental morphology and function.
MedLine Citation:
PMID:  22565610     Owner:  NLM     Status:  MEDLINE    
Gestational pemphigoid (PG), a very rare pregnancy-associated bullous dermatosis, is associated with adverse pregnancy outcome (miscarriage, preterm delivery, foetal growth restriction). The major antigen in PG is collagen XVII (BP180). PG autoantibodies cross-react with collagen XVII in the skin and have been suggested to cause placental failure. On this basis, we evaluated clinical outcome and morphological and functional placental data of 12 PG pregnancies in Finland during 2002 to 2011. The placental-to-birth weight ratio was abnormal in half of the pregnancies. Ultrastructural analysis of PG placentas showed detachment of basement membranes and undeveloped hemidesmosomes. Ultrasound evaluations of placental function prior to delivery were normal in all but one pregnancy. Three (25%) neonates were delivered preterm after 35 gestational weeks and one pregnancy was complicated by preeclampsia and severe foetal growth restriction. Neonatal outcome was uneventful in every case. In conclusion, in pregnancies complicated by PG, slight alteration in ultrastructural morphology of the placental basement membrane was detected, but umbilical artery Doppler evaluation indicated no functional placental changes.
Laura Huilaja; Kaarin Mäkikallio; Raija Sormunen; Jouko Lohi; Tiina Hurskainen; Kaisa Tasanen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  93     ISSN:  1651-2057     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-05-28     Revised Date:  2013-12-02    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  33-8     Citation Subset:  IM    
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MeSH Terms
Basement Membrane / pathology
Birth Weight
Fetal Growth Retardation
Infant, Newborn
Microscopy, Electron, Transmission
Organ Size
Pemphigoid Gestationis / pathology*
Placenta / pathology*,  ultrasonography*
Premature Birth
Prospective Studies
Pruritus / etiology
Ultrasonography, Prenatal
Umbilical Arteries / ultrasonography
Reg. No./Substance:
0/Glucocorticoids; 9PHQ9Y1OLM/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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