| Gestational glucose tolerance and cord blood leptin levels predict slower weight gain in early infancy. | |
| | |
MedLine Citation:
|
PMID: 20855080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine the extent to which known prenatal and perinatal predictors of childhood obesity also predict weight gain in early infancy. STUDY DESIGN: We studied 690 infants participating in the prospective cohort Project Viva. We measured length and weight at birth and at 6 months. Using multivariable linear regression, we examined relationships of selected maternal and infant factors with change in weight-for-length z-score (WFL-z) from 0 to 6 months. RESULTS: Mean (standard deviation) change in WFL-z from 0 to 6 months was 0.23 (1.11), which translates to 4500 grams gained from birth to 6 months of life in an infant with average birth weight and length. After adjustment for confounding variables and birth weight-for-gestational age z-score (-0.28 [95% confidence interval, -0.37, -0.19] per unit), cord blood leptin (-0.40 [95%confidence interval, -0.61, -0.19] per 10 ng/mL), and gestational diabetes -0.50 [95%confidence interval, -0.88, -0.11] versus normal glucose tolerance)were each associated with slower gain in WFL-z from 0 to 6 months. CONCLUSIONS: Higher neonatal leptin and gestational diabetes predicted slower weight gain in the first 6 months of life. The hormonal milieu of the intrauterine environment may determine growth patterns in early infancy and thus later obesity. |
| | |
Authors:
|
Margaret Parker; Sheryl L Rifas-Shiman; Mandy B Belfort; Elsie M Taveras; Emily Oken; Christos Mantzoros; Matthew W Gillman |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-19 |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 158 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-17 Completed Date: 2011-02-24 Revised Date: 2011-10-19 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
|
Languages: eng Pagination: 227-33 Citation Subset: AIM; IM |
Affiliation:
|
Division of Newborn Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, USA. margaret.parker@childrens.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Markers
/
blood Blood Glucose / analysis* Body Height Body Mass Index Child Development / physiology Cohort Studies Confidence Intervals Diabetes, Gestational / blood*, physiopathology Female Fetal Blood / chemistry* Follow-Up Studies Gestational Age Glucose Intolerance Glucose Tolerance Test Humans Infant Infant, Newborn Leptin / blood* Male Multivariate Analysis Odds Ratio Predictive Value of Tests Pregnancy Prospective Studies Regression Analysis Sensitivity and Specificity Time Factors Weight Gain / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
HD034568/HD/NICHD NIH HHS; HL 064925/HL/NHLBI NIH HHS; HL 068041/HL/NHLBI NIH HHS; P30 DK040561-15/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Blood Glucose; 0/Leptin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with ...
Next Document: Liver Metabolomic Changes Identify Biochemical Pathways in Hemorrhagic Shock.