Document Detail

Germinal center cell lymphomas: prognostic significance of their histopathological differentiation.
MedLine Citation:
PMID:  7343015     Owner:  NLM     Status:  MEDLINE    
Clinical data of 48 patients with centrocytic, 83 patients with centroblastic/centrocytic and 64 patients with centroblastic lymphoma who had entered a prospective multicenter study of the Kiel Lymphoma Study Group since October 1975 were compared. Advanced (stage IV) disease at time of diagnosis, predominantly due to bone marrow infiltration, was most frequent in centrocytic (69% of patients) and in centroblastic/centrocytic (51% of patients) lymphomas as compared to only 28% of patients with centroblastic lymphoma. High survival probability of patients with localized centrocytic and centroblastic/centrocytic lymphomas after radiotherapy, contrasting with a worse prognosis of corresponding patients with centroblastic lymphoma, is compatible with the classification of these lymphoma entities as neoplasias of low-grade malignancy. However, as shown by this prospective and previous retrospective trials overall survival probability of patients with advanced centrocytic lymphoma was inferior to that observed in corresponding patients with centroblastic/centrocytic lymphoma. These findings suggest the possibility that patients with advanced centrocytic lymphoma occupy an intermediate position between typical low-grade and typical high-grade malignant non-Hodgkin lymphomas.
E König; H Bartels; K Bremer; A Burger-Schüler; H Common; E Dühmke; M Engelhard; H H Fülle; U Gunzer; K M Koeppen; H Leopold; L Nowicki; J Oertel; S Paetzmann; U Rühl; M Schmidt; A Schoengen; H Scholle; A Stacher; B Wolf-Hornung; E W Schwarze; G Brittinger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blut     Volume:  43     ISSN:  0006-5242     ISO Abbreviation:  Blut     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1982-08-26     Completed Date:  1982-08-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0173401     Medline TA:  Blut     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  193-200     Citation Subset:  IM    
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MeSH Terms
Lymphoma / drug therapy,  pathology*
Middle Aged

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