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Germinal center B-cell-like diffuse large B-cell lymphoma of the duodenum is associated with t(14;18) translocation.
MedLine Citation:
PMID:  22126382     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Diffuse large B-cell lymphoma (DLBCL) rarely involves the duodenum, and its clinicopathological characteristics have not been well elucidated. We performed clinicopathological examinations and identified 15 patients with duodenal DLBCL using 18 gastric or colonic DLBCL as a control. Eleven of the 15 patients (73%) were subclassified by immunohistochemical analysis according to the Choi algorithm as germinal center B-cell-like (GCB) type, whereas the 18 control gastric and colonic DLBCL were predominantly subclassified as activated B-cell-like (ABC) type. The classifications according to organ involvement were statistically significant (P= 0.011 and P= 0.035). Macroscopically, the GCB lesions were varied, while all ABC lesions were ulcerative. Fluorescence in situ hybridization analysis revealed a higher frequency of t(14;18) translocation in patients with duodenal DLBCL (3 of 13) as compared with non-duodenal gastrointestinal tract DLBCL (0 of 18), however, the difference was not significant (P = 0.064). Furthermore, the three patients with t(14;18) translocations were classified as GCB. In addition, overall survival of patients was statistically different between those with and without t(14;18) translocation (P= 0.040). In conclusion, duodenal DLBCL predominantly exhibits GCB-type tumors and the frequency of t(14;18) translocation appears to be higher in duodenal GCB-type DLBCL compared to non-duodenal tumors.
Authors:
Maiko Tamura; Katsuyoshi Takata; Yasuharu Sato; Naoya Nakamura; Yara Yukie Kikuti; Koichi Ichimura; Takehiro Tanaka; Akira Tari; Yoshinobu Maeda; Mitsune Tanimoto; Hiroyuki Okada; Tadashi Yoshino
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  61     ISSN:  1440-1827     ISO Abbreviation:  Pathol. Int.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  742-8     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Pathology International © 2011 Japanese Society of Pathology and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Departments of Pathology Hematology, Oncology and Respiratory Medicine Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama Department of Pathology, Tokai University School of Medicine, Isehara, Kanagawa Department of Internal Medicine, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital, Hiroshima, Japan.
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