| The German multicenter trial of anisoylated plasminogen streptokinase activator complex versus heparin for acute myocardial infarction. | |
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MedLine Citation:
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PMID: 3046283 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A multicenter randomized trial of anisoylated plasminogen streptokinase activator complex (APSAC) versus heparin in patients with acute myocardial infarction of less than 4 hours' duration was undertaken in 19 hospitals. Of the 313 patients, 151 received heparin and 162 APSAC (30 U as intravenous injection). Within 28 days of hospital stay, 19 deaths (12.6%) occurred in the heparin group and 9 deaths (5.6%) in the APSAC group (p = 0.032). After 24 hours, patients in the APSAC group had a significantly lower incidence of cardiogenic shock (3.2 vs 9.5%, p = 0.031), asystole (3.8 vs 10.8%, p = 0.015) and need for resuscitation (5.1 vs 11.5%, p = 0.039). There was no difference in global and infarct-related ejection fraction between the 2 groups. Thus, APSAC favorably influences prognosis and clinical course in hospital. |
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Authors:
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T Meinertz; W Kasper; M Schumacher; H Just |
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10684423 - Characterization of magnesium sulfate as an antiarrhythmic agent. 15773233 - Potassium, magnesium, and electrolyte imbalance and complications in disease management. 10745543 - Electromechanical characterization of acute experimental myocardial infarction. |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of cardiology Volume: 62 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-09-30 Completed Date: 1988-09-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 347-51 Citation Subset: AIM; IM |
Affiliation:
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Medical Clinic III, University of Freiburg, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anistreplase Arteries Clinical Trials as Topic Coronary Vessels / physiopathology Creatine Kinase / blood Fibrinogen / blood Heart / physiopathology Heart Ventricles Heparin / adverse effects, therapeutic use* Humans Myocardial Infarction / complications, drug therapy*, mortality Plasminogen / adverse effects, blood, therapeutic use* Streptokinase / adverse effects, therapeutic use* Vascular Patency |
| Chemical | |
Reg. No./Substance:
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81669-57-0/Anistreplase; 9001-32-5/Fibrinogen; 9001-91-6/Plasminogen; 9005-49-6/Heparin; EC 2.7.3.2/Creatine Kinase; EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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