| Germ versus soma decisions: lessons from flies and worms. | |
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MedLine Citation:
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PMID: 17446385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The early embryo is formed by the fusion of two germ cells that must generate not only all of the nonreproductive somatic cell types of its body but also the germ cells for the next generation. Therefore, embryo cells face a crucial decision: whether to develop as germ or soma. How is this fundamental decision made and germ cell fate maintained during development? Studies in the nematode worm Caenorhabditis elegans and fruit fly Drosophila identify some of the decision-making strategies, including segregation of a specialized germ plasm and global transcriptional regulation. |
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Authors:
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Susan Strome; Ruth Lehmann |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 316 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-20 Completed Date: 2007-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
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Languages: eng Pagination: 392-3 Citation Subset: IM |
Affiliation:
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Department of Biology, Indiana University, Bloomington, IN 47405, USA. sstrome@indiana.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans / embryology*, genetics Caenorhabditis elegans Proteins / metabolism Cell Differentiation Cell Division Cell Lineage Drosophila / embryology*, genetics Drosophila Proteins / metabolism Embryo, Nonmammalian / cytology*, physiology Embryonic Development Gene Expression Regulation, Developmental Germ Cells / cytology*, physiology Organelles / physiology Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/Drosophila Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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