Document Detail

Germ versus soma decisions: lessons from flies and worms.
MedLine Citation:
PMID:  17446385     Owner:  NLM     Status:  MEDLINE    
The early embryo is formed by the fusion of two germ cells that must generate not only all of the nonreproductive somatic cell types of its body but also the germ cells for the next generation. Therefore, embryo cells face a crucial decision: whether to develop as germ or soma. How is this fundamental decision made and germ cell fate maintained during development? Studies in the nematode worm Caenorhabditis elegans and fruit fly Drosophila identify some of the decision-making strategies, including segregation of a specialized germ plasm and global transcriptional regulation.
Susan Strome; Ruth Lehmann
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  316     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-20     Completed Date:  2007-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  392-3     Citation Subset:  IM    
Department of Biology, Indiana University, Bloomington, IN 47405, USA.
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MeSH Terms
Caenorhabditis elegans / embryology*,  genetics
Caenorhabditis elegans Proteins / metabolism
Cell Differentiation
Cell Division
Cell Lineage
Drosophila / embryology*,  genetics
Drosophila Proteins / metabolism
Embryo, Nonmammalian / cytology*,  physiology
Embryonic Development
Gene Expression Regulation, Developmental
Germ Cells / cytology*,  physiology
Organelles / physiology
Transcription, Genetic
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/Drosophila Proteins

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