Document Detail


Germ cells: the eternal link between generations.
MedLine Citation:
PMID:  17631440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pluripotent epiblast cells in the early embryo are destined to form both the somatic cells and primordial germ cells. In the few cells that undergo specification to establish the germ cell lineage, there is repression of the somatic programme. Recent evidence shows that, Blimp1, a known transcriptional repressor with a SET/PR domain, is crucial for the specification of primordial germ cells (PGC). Blimp1 has the role, at least in part, of suppressing the somatic programme.
Authors:
M Azim Surani
Publication Detail:
Type:  Journal Article; Review     Date:  2007-05-09
Journal Detail:
Title:  Comptes rendus biologies     Volume:  330     ISSN:  1631-0691     ISO Abbreviation:  C. R. Biol.     Publication Date:    2007 Jun-Jul
Date Detail:
Created Date:  2007-07-16     Completed Date:  2007-09-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101140040     Medline TA:  C R Biol     Country:  France    
Other Details:
Languages:  eng     Pagination:  474-8     Citation Subset:  IM    
Affiliation:
Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. a.surani@gurdon.cam.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Diversity
Cell Lineage / genetics
Embryo, Mammalian / cytology
Female
Genomic Imprinting
Germ Cells / physiology*
Humans
Male
Oocytes
Parthenogenesis
Pluripotent Stem Cells
Pregnancy
Spermatozoa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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