| Germ cell tumours in neonates and infants: a distinct subgroup? | |
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MedLine Citation:
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PMID: 12752256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human germ cell tumours (GCTs) constitute a heterogeneous group of tumours that can be classified into four major subgroups. One of these subgroups encompasses (immature) teratomas and yolk sac tumours of patients under the age of 5 years. In this paper we review the various clinical, histological and cytogenetical aspects of these infantile GCTs. The primordial germ cell (PGC) has been suggested to be the cell of origin for GCTs. Infantile GCTs, however, have been suggested to originate from PGCs at a different stage of maturation than adult GCTs. The cytogenetic constitution of infantile GCTs also appears to differ from the adult GCTs and includes recurrent losses of lp and 6q. Recently, two cases of infantile GCT were detected with constitutional 12q13 translocations. These exceptional cases may be instrumental in the search for candidate genes related to infantile and/or adult GCT development. |
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Authors:
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Imke M Veltman; Marga T Schepens; Leendert H J Looijenga; Louise C Strong; Ad Geurts van Kessel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 111 ISSN: 0903-4641 ISO Abbreviation: APMIS Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-05-19 Completed Date: 2003-06-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: Denmark |
Other Details:
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Languages: eng Pagination: 152-60; discussion 160 Citation Subset: IM |
Affiliation:
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Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands. i.veltman@antrg.UMCN.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations Chromosome Mapping Chromosomes, Human, Pair 12 Germinoma / epidemiology, pathology* Humans Infant Infant, Newborn Karyotyping Male Sacrococcygeal Region* Teratoma / epidemiology, genetics, pathology* Translocation, Genetic |
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