Document Detail


Germ-cell sensitivity in mammals.
MedLine Citation:
PMID:  7167539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The differences in mammalian germ-cell sensitivity have been studied with a number of mutagenic agents using both chromosomal aberrations and point mutations as genetic endpoints. I have tried to give a survey on the present knowledge. Several conclusions can be drawn at present: 1. In spermatogenesis the sensitivity to mutation induction differs between various post-spermatogonial stages and spermatogonia. 2. Heritable structural chromosomal changes are primarily recovered from post-spermatogonial germ cells. The sensitivity pattern is similar in dominant lethal and heritable translocation experiments. The effect recovered from spermatogonia is near zero. 3. Structurally related chemicals show a difference in their spermatogenic response. The most obvious example gave the induction of specific locus mutations by ENU and MNU. 4. Since too little information is available it seems prudent to assume that oocytes and spermatogonia may show similar sensitivity so that in risk estimates effects on female germ cells cannot be neglected. The final result from the previous discussion must be that the limitations of knowledge are obvious, they lie in the limited number of chemicals tested in mammalian germ-cell assays. A larger data base of mammalian germ-cell response to chemical mutagens is urgently needed.
Authors:
I D Adler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Progress in clinical and biological research     Volume:  109     ISSN:  0361-7742     ISO Abbreviation:  Prog. Clin. Biol. Res.     Publication Date:  1982  
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7605701     Medline TA:  Prog Clin Biol Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-48     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chromosome Aberrations
Female
Germ Cells / drug effects*
Humans
Male
Mice
Mutagens* / pharmacology
Oocytes / drug effects
Spermatozoa / drug effects,  radiation effects,  ultrastructure
Chemical
Reg. No./Substance:
0/Mutagens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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