Document Detail

Germ cell migration and early development of the gonads in the trisomy 16 mouse--an animal model for Down's syndrome.
MedLine Citation:
PMID:  10363106     Owner:  NLM     Status:  MEDLINE    
The aneuploid condition of patients with Down's syndrome (trisomy 21) frequently leads to a sub- or infertility of these individuals. Gonads from adults and fetuses with trisomy 21 demonstrated histologically a remarkable reduction in germ cells. Disorders in the germ cell migration, the early development of the gonads as well as meiotic defects are thought to contribute to this pathomorphology. To gain information about premeiotic defects, investigations on the trisomy 16 mouse, an animal model for Down's syndrome, were carried out. By means of morphometric studies a delay in migration and a reduction in primordial germ cells was evaluated in trisomic mice of embryonic day 11 (E11). At day E13 a generalized growth retardation of the developing gonads was obvious in trisomic animals. Additionally performed electron microscopic examinations revealed signs of germ cell demise in trisomy 16 mice. Thus, the mechanisms of a diminished proliferation capacity, impaired migration and premature death of germ cells represent premeiotic disorders that presumably contribute to the pathomorphology observed in the gonads of individuals with Down's syndrome.
A Leffler; M Ludwig; O Schmitt; L C Busch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft     Volume:  181     ISSN:  0940-9602     ISO Abbreviation:  Ann. Anat.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-13     Completed Date:  1999-07-13     Revised Date:  2005-05-18    
Medline Journal Info:
Nlm Unique ID:  100963897     Medline TA:  Ann Anat     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  247-52     Citation Subset:  IM    
Department of Anatomy, Medical University of Lübeck, Germany.
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MeSH Terms
Alkaline Phosphatase / analysis
Chromosome Mapping
Crosses, Genetic
Disease Models, Animal
Down Syndrome / embryology*,  genetics,  pathology
Genitalia, Female / embryology*,  pathology
Genitalia, Male / embryology*,  pathology
Germ Cells / pathology,  physiology*
Gestational Age
Mice, Inbred Strains
Mice, Mutant Strains
Mullerian Ducts / embryology,  pathology
Reg. No./Substance:
EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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