| Geranylgeranylacetone protects against morphine-induced hepatic and renal damage in mice. | |
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MedLine Citation:
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PMID: 23229517 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The acute or chronic administration of opioid drugs may induce oxidative damage and cellular apoptosis in the liver and kidney, and hence result in hepatic and renal damage. Thioredoxin-1 (Trx-1) and heat shock protein 70 (Hsp70) are emerging as important modulators of cellular functions. They have been shown to be involved in cellular protective mechanisms against a variety of toxic stressors. The present study was designed to investigate the effects of geranylgeranylacetone (GGA), a pharmacological inducer of Trx-1 and Hsp70, on morphine-induced hepatic and renal damage. Morphine induced apoptosis in the liver and kidney through the mitochondria-mediated apoptosis pathway, but not the endoplasmic reticulum-mediated pathway. The activation of caspases-9 and -3 was attenuated by pre‑treatment with GGA. In addition, the morphine-induced increase of malondialdehyde (MDA) levels was suppressed by GGA. Furthermore, GGA enhanced morphine-induced expression of Trx-1 and Hsp70 in the liver and kidney. The findings of this study suggest that GGA may be a safe and novel therapeutic agent for morphine‑induced hepatic and renal damage. |
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Authors:
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Fu-Cheng Luo; Lu Zhao; Juan Deng; Min Liang; Xian-Si Zeng; Hua Liu; Jie Bai |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-03 |
Journal Detail:
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Title: Molecular medicine reports Volume: - ISSN: 1791-3004 ISO Abbreviation: Mol Med Report Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Report Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Medical Faculty, Kunming University of Science and Technology, Kunming 650500, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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